| Progress in pathogenesis and management of clinical intraamniotic infection. | |
| | |
MedLine Citation:
|
PMID: 2035575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the past decade, gratifying progress has been achieved in our understanding of clinical intraamniotic infection. With a usual incidence of 1% to 4%, clinical intraamniotic infection mainly develops as an ascending process after prolonged rupture of the membranes and labor, but other cases may be hematogenous in origin whereas still others complicate intrauterine procedures. The most common organisms isolated in amniotic fluid of cases of intraamniotic infections are anaerobes, genital mycoplasmas, group B streptococci, and Escherichia coli. The latter two are found most commonly in maternal or neonatal bacteremia complicating intraamniotic infection. Although the diagnosis remains largely a clinical one, laboratory tests have been suggested to confirm the diagnosis in women with symptoms. These include amniotic fluid Gram stain, gas-liquid chromatography, and leukocyte esterase measurement. Maternal treatment consists of antibiotic therapy and delivery. Studies to date have used a penicillin plus an aminoglycoside, with some authors advocating the addition of clindamycin after cesarean delivery. Other broad-spectrum regimens may be equally effective. Complications of clinical intraamniotic infections include an increase in cesarean section rate and in maternal and neonatal bacteremia. Poor neonatal outcomes in intraamniotic infection are more likely in the following cases: (1) when E. coli or group B streptococci are present in the amniotic fluid; (2) when the infant has a low birth weight; (3) when maternal antibiotic therapy is delayed until after delivery. |
| | |
Authors:
|
R S Gibbs; P Duff |
Related Documents
:
|
23627305 - Dual infection by streptococcus and atypical mycobacteria following ahmed glaucoma valv... 18061395 - Onset of streptococcal toxic shock syndrome is accelerated by bruising in a mouse model. 2114035 - Targeted immunoglobulin therapy for the prevention of neonatal infections. 12113845 - Fulminant infection and toxic shock syndrome caused by streptococcus pyogenes. 18679995 - Experimental infection of chickens with nocardia asteroides and nocardia transvalensis. 17517415 - Transmission of leishmania metacyclic promastigotes by phlebotomine sand flies. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 164 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1991 May |
Date Detail:
|
Created Date: 1991-06-21 Completed Date: 1991-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1317-26 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver 80262. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amniotic Fluid
/
microbiology Ampicillin / therapeutic use Bacterial Infections / diagnosis, etiology*, therapy Birth Weight Chorioamnionitis / diagnosis, drug therapy, etiology* Chromatography, Gas Clindamycin / therapeutic use Drug Combinations Esterases / biosynthesis Extraembryonic Membranes / microbiology Female Gentamicins / therapeutic use Humans Leukocytes / enzymology Leukocytosis / diagnosis Obstetric Labor Complications / etiology Pregnancy Pregnancy Complications, Infectious* Risk |
| Chemical | |
Reg. No./Substance:
|
0/Drug Combinations; 0/Gentamicins; 18323-44-9/Clindamycin; 69-53-4/Ampicillin; EC 3.1.-/Esterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The clinical utility of maternal body mass index in pregnancy.
Next Document: Endothelin and neuropeptide Y are vasoconstrictors in human uterine blood vessels.