Document Detail


Progress in lipid reporting practices and reliability of blood cholesterol measurement in clinical laboratories in Nebraska. Efforts to align results with the Centers for Disease Control, and feasibility of meeting National Cholesterol Education Program Guidelines.
MedLine Citation:
PMID:  2543838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The National Cholesterol Education Program has recommended that all laboratories be consistent, precise, and accurate in the reporting and measurement of blood cholesterol levels. In a follow-up to a 1984 survey study, we assessed the changes in reporting procedures for measurements of blood lipid levels in 16 clinical laboratories in Nebraska. Using human serum reference materials of known cholesterol concentrations provided by the Centers for Disease Control, we also assessed the precision and accuracy of measurement of blood cholesterol levels in clinical laboratories in Nebraska. Fourteen of the 16 laboratories restudied in 1987 had altered the reference range for total serum cholesterol since 1984, 86% of whom lowered the upper limit of the reference range. Eleven of 16 laboratories expressed reference ranges for total serum cholesterol in terms of patient age in 1987, while only 7 of 20 did in 1984. Gender-based reference ranges increased from 0 to 5 from 1984 to 1987. Similar trends were seen in the reporting of high-density lipoprotein cholesterol and triglyceride concentrations. Reporting procedures varied greatly; only 1 laboratory used National Cholesterol Education Program risk levels for measuring total serum cholesterol levels. Fifteen laboratories met the National Cholesterol Education Program recommendation for precision (coefficient of variation, less than or equal to 5%) and 78% of laboratories obtained results that satisfied the current recommendation for accuracy (within 5% of "true value," as determined by the Centers for Disease Control).
Authors:
B M McManus; A B Toth; J A Engel; G L Myers; H K Naito; J E Wilson; G R Cooper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA     Volume:  262     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-07-20     Completed Date:  1989-07-20     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Centers for Disease Control and Prevention (U.S.)
Cholesterol / blood*
Feasibility Studies
Follow-Up Studies
Humans
Laboratories / standards*
Lipoproteins, LDL / blood
Male
Nebraska
Questionnaires
Reference Values
Sex Factors
Triglycerides / blood
United States
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL; 0/Triglycerides; 97C5T2UQ7J/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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