Document Detail

Progress in diagnosis of hepatitis and the cirrhotic liver.
MedLine Citation:
PMID:  10219695     Owner:  NLM     Status:  MEDLINE    
History of the concept and definition of hepatitis is briefly reviewed. The landmarks of progress are based on better understanding of liver structure and introduction of biopsy techniques to follow the pathologic alterations in acute and chronic hepatitis, cirrhosis, dysplasia and hepatoma. Modern achievements are recognition of the etiologic agents of viral hepatitis A through G, viral nucleic acid sequencing, viral genome and gene products leading to development of immunologic tests to etiologic diagnosis. Viral particles are visualized by electron microscopy. In tissue, localization of viral products is obtained by histochemical, immunologic and by in situ hybridization methods. Diagnostic criteria for each of the viral etiologic agents is reviewed, as is cirrhosis and its occurrence in viral hepatitis and alcohol abuse.
J G Szakacs; J E Szakacs
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  29     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:    1999 Apr-Jun
Date Detail:
Created Date:  1999-06-16     Completed Date:  1999-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-103     Citation Subset:  IM; Q    
Department of Pathology, Salt Lake City VAMC, UT 84148, USA.
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MeSH Terms
Hepatitis / diagnosis,  history*
Hepatitis, Autoimmune / diagnosis,  history
Hepatitis, Viral, Human / diagnosis,  history
History, 17th Century
History, 18th Century
History, 19th Century
History, 20th Century
History, Ancient
Liver Cirrhosis / diagnosis,  history*

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