Document Detail


Progress in primary aldosteronism: present challenges and perspectives.
MedLine Citation:
PMID:  20091458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary Aldosteronism (PA) is a disorder of the adrenal zona glomerulosa (ZG) in which aldosterone secretion is increased and is relatively autonomous of normal regulatory mechanisms. A recent conference in Munich organized by Prof. Reincke addressed advances and challenges related to the screening, diagnosis, and identification of uni- and bilateral involvement of the diseased adrenal of PA. Some infrequently addressed issues are described herein. We postulate that most cases of PA are due to the activation by unknown mechanisms of subset of cells resulting in the formation of a multiple foci or nodules of hyperactive zona glomerulosa cells. This implies that one or several yet unidentified stimuli can drive aldosterone overproduction, as well as the proliferation of aldosterone-producing cells. Current diagnostic procedures allow to determine whether inappropriate aldosterone production is driven by one or both adrenal glands and thus to establish optimal treatment.
Authors:
C E Gomez-Sanchez; G P Rossi; F Fallo; M Mannelli
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-01-20
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  42     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  374-81     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart-New York.
Affiliation:
Division of Endocrinology, G V (Sonny) Montgomery VA Medical Center, Jackson, MS 39216, USA. cgomez-sanchez@medicine.umsmed.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Neoplasms / complications,  diagnosis,  metabolism
Adrenocortical Adenoma / complications,  diagnosis,  metabolism
Aldosterone / blood
Diagnosis, Differential
Endocrinology / methods,  trends*
Goiter, Nodular / diagnosis,  metabolism
Humans
Hyperaldosteronism / blood,  diagnosis,  etiology,  therapy*
Renin / blood
Chemical
Reg. No./Substance:
52-39-1/Aldosterone; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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