| Progress in primary aldosteronism: present challenges and perspectives. | |
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MedLine Citation:
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PMID: 20091458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary Aldosteronism (PA) is a disorder of the adrenal zona glomerulosa (ZG) in which aldosterone secretion is increased and is relatively autonomous of normal regulatory mechanisms. A recent conference in Munich organized by Prof. Reincke addressed advances and challenges related to the screening, diagnosis, and identification of uni- and bilateral involvement of the diseased adrenal of PA. Some infrequently addressed issues are described herein. We postulate that most cases of PA are due to the activation by unknown mechanisms of subset of cells resulting in the formation of a multiple foci or nodules of hyperactive zona glomerulosa cells. This implies that one or several yet unidentified stimuli can drive aldosterone overproduction, as well as the proliferation of aldosterone-producing cells. Current diagnostic procedures allow to determine whether inappropriate aldosterone production is driven by one or both adrenal glands and thus to establish optimal treatment. |
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Authors:
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C E Gomez-Sanchez; G P Rossi; F Fallo; M Mannelli |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-20 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 42 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 374-81 Citation Subset: IM |
Copyright Information:
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Georg Thieme Verlag KG Stuttgart-New York. |
Affiliation:
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Division of Endocrinology, G V (Sonny) Montgomery VA Medical Center, Jackson, MS 39216, USA. cgomez-sanchez@medicine.umsmed.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Neoplasms
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complications,
diagnosis,
metabolism Adrenocortical Adenoma / complications, diagnosis, metabolism Aldosterone / blood Diagnosis, Differential Endocrinology / methods, trends* Goiter, Nodular / diagnosis, metabolism Humans Hyperaldosteronism / blood, diagnosis, etiology, therapy* Renin / blood |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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