Document Detail

Progress of emphysema in severe alpha 1-antitrypsin deficiency as assessed by annual CT.
MedLine Citation:
PMID:  9332238     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess serial CT as a measure of the progress of emphysema in patients with severe alpha 1-antitrypsin deficiency (phenotype PiZ). MATERIAL AND METHODS: In a randomized placebo-controlled study of alpha 1-antitrypsin augmentation therapy, 22 patients with moderate emphysema were followed for 2-4 years with an annual lung CT. The images were analysed by means of semiautomatic lung detection, and the degree of emphysema was quantitated by the density-mask and the percentile methods. The influence of lung volume was standardised by a regression model. RESULTS: A highly significant decline in Hounsfield units (HU) was found in low-density areas, corresponding to a mean (SE) annual loss of lung tissue of 2.1 (0.4) g/l lung volume. Analysis of a single slice at 5 cm below the level of the carina gave comparable results: 2.4 (0.4) g/l. CONCLUSION: Serial CT is a sensitive measure of the progress of emphysema in patients with severe alpha 1-antitrypsin deficiency.
A Dirksen; M Friis; K P Olesen; L T Skovgaard; K Sørensen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  38     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-05     Completed Date:  1997-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  826-32     Citation Subset:  IM    
Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
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MeSH Terms
Acute Disease
Disease Progression
Lung / radiography*
Middle Aged
Pulmonary Emphysema / drug therapy,  physiopathology,  radiography*
Regression Analysis
Respiratory Function Tests / methods,  statistics & numerical data
Time Factors
Tomography, X-Ray Computed / instrumentation,  methods,  statistics & numerical data
Trypsin Inhibitors / therapeutic use
alpha 1-Antitrypsin / therapeutic use
alpha 1-Antitrypsin Deficiency / drug therapy,  physiopathology,  radiography*
Reg. No./Substance:
0/Trypsin Inhibitors; 0/alpha 1-Antitrypsin

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