Document Detail


Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development.
MedLine Citation:
PMID:  12889069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The growth factor progranulin (acrogranin/PC-derived growth factor/granulin-epithelin precursor) promotes onset of blastocyst cavitation and is required for neonatal hypothalamic sexual differentiation. Little is known, however, of the range of developmental processes in which it is involved. We used in situ hybridization to investigate progranulin expression in murine embryos. Progranulin mRNA is expressed in maternal and embryonic components during early establishment of pregnancy. Abundant expression is observed in the early decidualizing uterine stroma and glands. In the embryo, the trophoblast giant cells at the interface of placental exchange sites (both choriovitelline and chorioallantoic placenta) show strong expression. The gastrulating epiblast and mesenchyme (intraembryonic and extraembryonic mesenchyme) all revealed activity. The allantois and yolk sac mesenchyme (site of early hemopoiesis) were positive, as were later phases of active vessel formation (pia mater of brain, epicardium of the heart). In the urogenital system, it was expressed in Sertoli cells and in kidney tubules. It was highly expressed in proliferating epidermal cells. During epidermal appendage formation, the early epithelial bud was positive, but the forming duct and differentiating adjacent mesenchyme was negative. It is widely distributed during central nervous system development and the peripheral nervous system (dorsal root ganglia and sympathetic ganglia). Based on the pattern of progranulin gene expression, we propose proliferative and developmental roles for progranulin in establishing pregnancy, during gastrulation, and during embryonic development of the epidermis, nervous system, blood vessel, formation, and spermatogenesis.
Authors:
Rachael Daniel; Eugene Daniels; Zhiheng He; Andrew Bateman
Related Documents :
23090999 - Transcription factor atf5 is required for terminal differentiation and survival of olfa...
21273249 - Role of flbt on the flagellin production in brucella melitensis.
22937869 - Identification of the streptococcus mutans lytst two-component regulon reveals its cont...
11424209 - Ran binding protein ranbp1 in zebrafish embryonic development.
16319119 - P38 mapk is essential for secondary axis specification and patterning in sea urchin emb...
19747739 - Disruption of zebrafish (danio rerio) embryonic development after full life-cycle paren...
20943789 - Twist1 in human white adipose tissue and obesity.
20487379 - Abo3, a wrky transcription factor, mediates plant responses to abscisic acid and drough...
23897429 - Dnmt1 is regulated by atp-citrate lyase and maintains methylation patterns during adipo...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  227     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2004-04-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  593-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
Endocrine Research Laboratory, Royal Victoria Hospital, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessels / metabolism
Central Nervous System / metabolism
Embryo, Mammalian / embryology,  metabolism*
Epidermis / metabolism
Epithelium / metabolism
Female
Gene Expression Profiling*
Immunohistochemistry
In Situ Hybridization
Intercellular Signaling Peptides and Proteins / genetics,  metabolism*
Mice
Mice, Inbred BALB C
Placenta / metabolism
Chemical
Reg. No./Substance:
0/Grn protein, mouse; 0/Intercellular Signaling Peptides and Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development.
Next Document:  Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein.