Document Detail

Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development.
MedLine Citation:
PMID:  12889069     Owner:  NLM     Status:  MEDLINE    
The growth factor progranulin (acrogranin/PC-derived growth factor/granulin-epithelin precursor) promotes onset of blastocyst cavitation and is required for neonatal hypothalamic sexual differentiation. Little is known, however, of the range of developmental processes in which it is involved. We used in situ hybridization to investigate progranulin expression in murine embryos. Progranulin mRNA is expressed in maternal and embryonic components during early establishment of pregnancy. Abundant expression is observed in the early decidualizing uterine stroma and glands. In the embryo, the trophoblast giant cells at the interface of placental exchange sites (both choriovitelline and chorioallantoic placenta) show strong expression. The gastrulating epiblast and mesenchyme (intraembryonic and extraembryonic mesenchyme) all revealed activity. The allantois and yolk sac mesenchyme (site of early hemopoiesis) were positive, as were later phases of active vessel formation (pia mater of brain, epicardium of the heart). In the urogenital system, it was expressed in Sertoli cells and in kidney tubules. It was highly expressed in proliferating epidermal cells. During epidermal appendage formation, the early epithelial bud was positive, but the forming duct and differentiating adjacent mesenchyme was negative. It is widely distributed during central nervous system development and the peripheral nervous system (dorsal root ganglia and sympathetic ganglia). Based on the pattern of progranulin gene expression, we propose proliferative and developmental roles for progranulin in establishing pregnancy, during gastrulation, and during embryonic development of the epidermis, nervous system, blood vessel, formation, and spermatogenesis.
Rachael Daniel; Eugene Daniels; Zhiheng He; Andrew Bateman
Related Documents :
23259949 - Activity-dependent transcriptional regulation of m-type (kv7) k(+) channels by akap79/1...
19747739 - Disruption of zebrafish (danio rerio) embryonic development after full life-cycle paren...
23132569 - Heterologous expression of corn cystatin in soybean and effect on growth of the stink bug.
18729229 - Expression of protocadherin-1 (pcdh1) during mouse development.
22967709 - 1α,25-dihydroxyvitamin d3 and rosiglitazone synergistically enhance osteoblast-mediated...
24244499 - Integrated expression profiles of mrna and mirna in polarized primary murine microglia.
24095829 - Korean red ginseng extract induces proliferation to differentiation transition of human...
11443859 - Role of epstein-barr virus in burkitt's lymphoma.
12576599 - Differential expression of candida albicans phospholipase b (plb1) under various enviro...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  227     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2004-04-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  593-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Endocrine Research Laboratory, Royal Victoria Hospital, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Vessels / metabolism
Central Nervous System / metabolism
Embryo, Mammalian / embryology,  metabolism*
Epidermis / metabolism
Epithelium / metabolism
Gene Expression Profiling*
In Situ Hybridization
Intercellular Signaling Peptides and Proteins / genetics,  metabolism*
Mice, Inbred BALB C
Placenta / metabolism
Reg. No./Substance:
0/Grn protein, mouse; 0/Intercellular Signaling Peptides and Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development.
Next Document:  Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein.