| Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development. | |
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MedLine Citation:
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PMID: 12889069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The growth factor progranulin (acrogranin/PC-derived growth factor/granulin-epithelin precursor) promotes onset of blastocyst cavitation and is required for neonatal hypothalamic sexual differentiation. Little is known, however, of the range of developmental processes in which it is involved. We used in situ hybridization to investigate progranulin expression in murine embryos. Progranulin mRNA is expressed in maternal and embryonic components during early establishment of pregnancy. Abundant expression is observed in the early decidualizing uterine stroma and glands. In the embryo, the trophoblast giant cells at the interface of placental exchange sites (both choriovitelline and chorioallantoic placenta) show strong expression. The gastrulating epiblast and mesenchyme (intraembryonic and extraembryonic mesenchyme) all revealed activity. The allantois and yolk sac mesenchyme (site of early hemopoiesis) were positive, as were later phases of active vessel formation (pia mater of brain, epicardium of the heart). In the urogenital system, it was expressed in Sertoli cells and in kidney tubules. It was highly expressed in proliferating epidermal cells. During epidermal appendage formation, the early epithelial bud was positive, but the forming duct and differentiating adjacent mesenchyme was negative. It is widely distributed during central nervous system development and the peripheral nervous system (dorsal root ganglia and sympathetic ganglia). Based on the pattern of progranulin gene expression, we propose proliferative and developmental roles for progranulin in establishing pregnancy, during gastrulation, and during embryonic development of the epidermis, nervous system, blood vessel, formation, and spermatogenesis. |
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Authors:
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Rachael Daniel; Eugene Daniels; Zhiheng He; Andrew Bateman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 227 ISSN: 1058-8388 ISO Abbreviation: Dev. Dyn. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-30 Completed Date: 2004-04-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 593-9 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Endocrine Research Laboratory, Royal Victoria Hospital, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessels / metabolism Central Nervous System / metabolism Embryo, Mammalian / embryology, metabolism* Epidermis / metabolism Epithelium / metabolism Female Gene Expression Profiling* Immunohistochemistry In Situ Hybridization Intercellular Signaling Peptides and Proteins / genetics, metabolism* Mice Mice, Inbred BALB C Placenta / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Grn protein, mouse; 0/Intercellular Signaling Peptides and Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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