Document Detail


Programming the offspring of the pig by prenatal social stress: neuroendocrine activity and behaviour.
MedLine Citation:
PMID:  15961089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study provides evidence in the pig that stress experienced during gestation has long-lasting effects on offspring daughters, including their maternal behaviour. Thirty-six primiparous sows were divided into control and two groups that were stressed (by social mixing) during either the second (Mix 2) or third (Mix 3) trimester of pregnancy. We found detrimental effects of mixing on the mothers' growth, body lesions, and cortisol secretion, but did not observe any significant effects on reproductive parameters including birth weight. At 60 days of age, 48 daughters were randomly selected from the three treatments: half were challenged using a restraint and isolation test. Then, all were culled and brain tissue was collected. In situ hybridisation measurements showed increased expression of CRH mRNA in the PVN in unrestrained Mix 2 and in the amygdala of Mix 2 and Mix 3 daughters. At 67 days, 24 further daughters were mixed to measure their responses to this social stress. All showed increased salivary cortisol secretion, but Mix 2 and Mix 3 daughters showed a greater and longer response than controls. Finally, all 24 were inseminated and at parturition maternal behaviour was measured. Mix 2 and Mix 3 daughters were more restless and more responsive to piglets that approached the head of the sow, traits which previously have been shown to be a component of abnormal maternal behaviour. Indeed, Mix 2 and Mix 3 daughters also tended to bite at their piglets more than control daughters.
Authors:
Susan Jarvis; Christine Moinard; Sheena K Robson; Emma Baxter; Elisabeth Ormandy; Alison J Douglas; Jonathan R Seckl; John A Russell; Alistair B Lawrence
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-15
Journal Detail:
Title:  Hormones and behavior     Volume:  49     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-26     Completed Date:  2006-02-27     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology*
Body Weight / physiology
Corticotropin-Releasing Hormone / biosynthesis
Female
Hydrocortisone / metabolism
In Situ Hybridization
Maternal Behavior
Neurosecretory Systems / physiology*
Pregnancy
Prenatal Exposure Delayed Effects
RNA, Messenger / biosynthesis
Reproduction / physiology
Restraint, Physical
Saliva / metabolism,  physiology
Social Dominance
Stress, Psychological / physiopathology*,  psychology
Swine
Weaning
Weight Gain / physiology
Chemical
Reg. No./Substance:
0/RNA, Messenger; 9015-71-8/Corticotropin-Releasing Hormone; WI4X0X7BPJ/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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