Document Detail


Programming of cholesterol metabolism by breast or formula feeding.
MedLine Citation:
PMID:  1855416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the hypothesis that breast or formula feeding and cholesterol intake during the neonatal period influence cholesterol metabolism and arterial fatty streaks in young adult baboons. Genetic variation was controlled by randomly assigning half-sib sire progeny to a factorial dietary design. We measured serum cholesterol and lipoprotein cholesterol concentrations enzymically and cholesterol production and bile acid excretion rates isotopically. The bile cholesterol saturation index was calculated from enzymic analyses of cholesterol, bile salt and phospholipid concentrations in gallbladder bile. Breast-fed baboons had higher serum VLDL + LDL cholesterol/HDL cholesterol ratios in the early postweaning period (six months) until adulthood (7-8 years) than formula-fed baboons. In adulthood a high cholesterol diet increased bile acid excretion by approximately 40% in formula-fed baboons but did not significantly increase the bile acid excretion rate among breast-fed animals. Adult baboons breast fed as infants also had an approximately 8% lower cholesterol production rate than formula-fed animals and a 20% higher bile cholesterol saturation index. The level of cholesterol in the infant formulas influenced cholesterol metabolism in adulthood but not serum lipoprotein concentrations. As young adults, breast-fed baboons had more extensive arterial fatty streaks than formula-fed baboons. This difference could be accounted for by differences in the lipoprotein ratios. These results demonstrate that breast and formula feeding differentially modify cholesterol metabolism. This may influence the development of chronic diseases.
Authors:
G E Mott; D S Lewis; H C McGill
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  156     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-27     Completed Date:  1991-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  56-66; discussion 66-76     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Animals, Suckling
Breast Feeding*
Cholesterol / metabolism*
Cholesterol, Dietary / adverse effects
Humans
Infant
Infant Food*
Papio
Time Factors
Grant Support
ID/Acronym/Agency:
HL-15914/HL/NHLBI NIH HHS; HL-19362/HL/NHLBI NIH HHS; HL-28728/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, Dietary; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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