Document Detail

Programming of adult cardiovascular function after early maternal undernutrition in sheep.
MedLine Citation:
PMID:  14975924     Owner:  NLM     Status:  MEDLINE    
The prenatal nutritional environment influences the subsequent risk of hypertension in adulthood. Animal studies have used, generally, the rat as a model species to illustrate the association between maternal nutrient intake and blood pressure in the resulting adult offspring. No study to date has shown programming of adult cardiovascular function in the sheep through maternal dietary intervention. We therefore fed pregnant sheep to either 100% recommended intake from day 0 of gestation to term [ approximately 147 days gestational age (dGA); controls n = 8] or to 50% recommended intake from day 0 to 95 dGA and thereafter to 100% intake (NR; n = 9). Sheep lambed naturally, offspring were weaned at 16 wk, and the male offspring were reared on pasture until 3 yr of age. At this time, cardiovascular catheters were inserted under halothane anesthesia and sheep were allowed 2-4 days recovery. Basal cardiovascular status and pressor responses to infusion of norepinephrine, angiotensin II, and captopril were then assessed alongside basal plasma concentrations of glucose, cortisol, and leptin. NR sheep were of similar birth weight to controls but at 3 yr of age had higher blood pressure before, but not after, feeding. Peripheral sensitivity to vasoconstrictor infusion was similar between dietary groups, although a reflex bradycardia was not apparent in NR sheep during norepinephrine infusion. Circulating leptin correlated well with fat mass and increased more after vasoconstrictor infusion in NR sheep. In conclusion, early NR has been shown to program aspects of cardiovascular control and adipocyte function in adult sheep.
G S Gopalakrishnan; D S Gardner; S M Rhind; M T Rae; C E Kyle; A N Brooks; R M Walker; M M Ramsay; D H Keisler; T Stephenson; M E Symonds
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-02-19
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  287     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-11     Completed Date:  2004-07-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R12-20     Citation Subset:  IM    
Academic Division of Child Health, School of Human Development, Univ. Hospital, Nottingham NG7 2UH, UK.
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MeSH Terms
Angiotensin II / pharmacology
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Baroreflex / drug effects
Birth Weight
Blood Glucose / metabolism
Blood Pressure / drug effects,  physiology
Body Composition / physiology
Captopril / pharmacology
Heart Rate / drug effects,  physiology
Hemodynamics / drug effects,  physiology*
Hormones / blood
Hydrocortisone / blood
Leptin / blood
Norepinephrine / pharmacology
Placental Insufficiency / physiopathology*
Prenatal Exposure Delayed Effects*
Stress, Physiological / metabolism
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Blood Glucose; 0/Hormones; 0/Leptin; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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