| Programming of adult cardiovascular function after early maternal undernutrition in sheep. | |
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MedLine Citation:
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PMID: 14975924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prenatal nutritional environment influences the subsequent risk of hypertension in adulthood. Animal studies have used, generally, the rat as a model species to illustrate the association between maternal nutrient intake and blood pressure in the resulting adult offspring. No study to date has shown programming of adult cardiovascular function in the sheep through maternal dietary intervention. We therefore fed pregnant sheep to either 100% recommended intake from day 0 of gestation to term [ approximately 147 days gestational age (dGA); controls n = 8] or to 50% recommended intake from day 0 to 95 dGA and thereafter to 100% intake (NR; n = 9). Sheep lambed naturally, offspring were weaned at 16 wk, and the male offspring were reared on pasture until 3 yr of age. At this time, cardiovascular catheters were inserted under halothane anesthesia and sheep were allowed 2-4 days recovery. Basal cardiovascular status and pressor responses to infusion of norepinephrine, angiotensin II, and captopril were then assessed alongside basal plasma concentrations of glucose, cortisol, and leptin. NR sheep were of similar birth weight to controls but at 3 yr of age had higher blood pressure before, but not after, feeding. Peripheral sensitivity to vasoconstrictor infusion was similar between dietary groups, although a reflex bradycardia was not apparent in NR sheep during norepinephrine infusion. Circulating leptin correlated well with fat mass and increased more after vasoconstrictor infusion in NR sheep. In conclusion, early NR has been shown to program aspects of cardiovascular control and adipocyte function in adult sheep. |
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Authors:
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G S Gopalakrishnan; D S Gardner; S M Rhind; M T Rae; C E Kyle; A N Brooks; R M Walker; M M Ramsay; D H Keisler; T Stephenson; M E Symonds |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-02-19 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 287 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-11 Completed Date: 2004-07-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R12-20 Citation Subset: IM |
Affiliation:
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Academic Division of Child Health, School of Human Development, Univ. Hospital, Nottingham NG7 2UH, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Angiotensin II / pharmacology Angiotensin-Converting Enzyme Inhibitors / pharmacology Animals Baroreflex / drug effects Birth Weight Blood Glucose / metabolism Blood Pressure / drug effects, physiology Body Composition / physiology Captopril / pharmacology Female Heart Rate / drug effects, physiology Hemodynamics / drug effects, physiology* Hormones / blood Hydrocortisone / blood Leptin / blood Male Norepinephrine / pharmacology Placental Insufficiency / physiopathology* Pregnancy Prenatal Exposure Delayed Effects* Sheep Stress, Physiological / metabolism Vasoconstrictor Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Blood Glucose; 0/Hormones; 0/Leptin; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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