| Programmed to direct alloimmunity. | |
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MedLine Citation:
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PMID: 20551923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After an allograft placement, the body faces an intricate task of mounting a balanced immune response to foreign antigens. The ideal response entails maintaining enough immunity to prevent infections and cancer yet not endangering the ability to achieve and maintain organ tolerance. Programmed death-1 and its ligands expressed on non-professional antigen-presenting cells such as the renal tubular epithelium function to downregulate allogenic T-cell responses and thus play an important role in achieving this balance. |
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Authors:
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Sundararaman Swaminathan |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Kidney international Volume: 78 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-16 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 8-9 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Affairs Medical Center, Little Rock, Arkansas 72211, USA. sswaminathan@uams.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Presenting Cells / immunology Histocompatibility / immunology Humans Immune Tolerance / immunology* Immunity / immunology Mice T-Lymphocytes / immunology |
| Comments/Corrections | |
Comment On:
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Kidney Int. 2010 Jul;78(1):38-47
[PMID:
20393451
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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