Document Detail

Programmed cell death in Parkinson's disease.
MedLine Citation:
PMID:  22908196     Owner:  NLM     Status:  MEDLINE    
Parkinson's disease is a debilitating disorder characterized by a progressive loss of dopaminergic neurons caused by programmed cell death. The aim of this review is to provide an up-to-date summary of the major programmed cell death pathways as they relate to PD. For a long time, programmed cell death has been synonymous with apoptosis but there now is evidence that other types of programmed cell death exist, such as autophagic cell death or programmed necrosis, and that these types of cell death are relevant to PD. The pathways and signals covered here include namely the death receptors, BCL-2 family, caspases, calpains, cdk5, p53, PARP-1, autophagy, mitophagy, mitochondrial fragmentation, and parthanatos. The review will present evidence from postmortem PD studies, toxin-induced models (especially MPTP/MPP+, 6-hydroxydopamine and rotenone), and from α-synuclein, LRRK2, Parkin, DJ-1, and PINK1 genetic models of PD, both in vitro and in vivo.
Katerina Venderova; David S Park
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-08-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  2     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-21     Completed Date:  2013-06-26     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Apoptosis / physiology*
Autophagy / physiology
Caspases / physiology
Cyclin-Dependent Kinase 5 / physiology
DNA-Binding Proteins / physiology
Endoplasmic Reticulum / physiology
Mitochondrial Degradation / physiology
Mitochondrial Dynamics / physiology
Necrosis / physiopathology
Parkinson Disease / physiopathology*
Proto-Oncogene Proteins c-bcl-2 / physiology
Receptors, Death Domain / physiology*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/PDRG1 protein, human; 0/Proto-Oncogene Proteins c-bcl-2; 0/Receptors, Death Domain; EC Kinase 5; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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