Document Detail


Programmed cell death of follicular epithelium during the late developmental stages of oogenesis in the fruit flies Bactrocera oleae and Ceratitis capitata (Diptera, Tephritidae) is mediated by autophagy.
MedLine Citation:
PMID:  16573736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we describe the features of programmed cell death of ovarian follicle cells, occurring during the late developmental stages of oogenesis in the olive fruit fly, Bactrocera oleae and the medfly, Ceratitis capitata. During stage 14, the follicle cells contain autophagic vacuoles, and they do not exhibit caspase activity in all parts of the egg chamber. Their nuclei are characterized by condensed chromatin, accompanied with high- but not low-molecular weight DNA fragmentation events exclusively detected in distinct cells of the anterior pole. These data argue for the presence of an autophagy-mediated cell death program in the ovarian follicle cell layer in both species. The above results are likely associated with the abundant phagocytosis observed at the entry of the lateral oviducts, where numerous cell bodies are massively engulfed by epithelial cells. We strongly believe that during the termination of the above Dipteran oogenesis, an efficient mechanism of absorption of the degenerated follicle cells is selectively activated, in order to prevent the blockage of the ovarioles and thus robustly support the physiological completion of the ovulation process.
Authors:
Ioannis P Nezis; Dimitrios J Stravopodis; Lukas H Margaritis; Issidora S Papassideri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development, growth & differentiation     Volume:  48     ISSN:  0012-1592     ISO Abbreviation:  Dev. Growth Differ.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-31     Completed Date:  2006-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356504     Medline TA:  Dev Growth Differ     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  189-98     Citation Subset:  IM    
Affiliation:
Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 15784, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy / physiology*
Ceratitis capitata / cytology,  physiology*
Epithelial Cells / cytology,  ultrastructure
Epithelium / growth & development*
Female
Oogenesis / physiology*
Ovarian Follicle / cytology
Tephritidae / cytology,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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