Document Detail

Programmed cell death in a patient with hepatocellular carcinoma treated with yttrium-90 and doxorubicin-loaded beads.
MedLine Citation:
PMID:  24070510     Owner:  NLM     Status:  MEDLINE    
Molecular analysis of apoptosis and autophagy pathways was performed from a single hepatocellular carcinoma treated with yttrium-90 and doxorubicin-loaded beads before resection and compared with normal liver tissue from the margins. Both bead formulations activated apoptosis-associated mechanisms and increased autophagy pathway protein levels. Increased DNA fragmentation and autophagy markers were seen in tumor treated with drug-eluting beads compared with yttrium-90-treated tumor. These results suggest that both microembolic therapies activate cell death signaling, although differences in apoptosis and autophagy pathways were seen in this patient. Knowledge of mechanisms of action for each treatment may enhance future therapeutic strategies.
Robert Meller; Lorena Galvan; Jing Quan Lan; Esther Han; Jason Bauer; Katherine T Morris
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  24     ISSN:  1535-7732     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-27     Completed Date:  2014-04-25     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1537-42.e2     Citation Subset:  IM    
Copyright Information:
© SIR, 2013.
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MeSH Terms
Apoptosis Regulatory Proteins / metabolism*
Autophagy / drug effects,  radiation effects
Carcinoma, Hepatocellular / metabolism*,  therapy*
Chemoradiotherapy / methods
Delayed-Action Preparations / administration & dosage
Doxorubicin / administration & dosage*
Liver Neoplasms / metabolism*,  therapy*
Middle Aged
Radiopharmaceuticals / therapeutic use
Treatment Outcome
Yttrium Radioisotopes / therapeutic use*
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Capsules; 0/Delayed-Action Preparations; 0/Radiopharmaceuticals; 0/Yttrium Radioisotopes; 80168379AG/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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