| Prognostic values of perfusion-metabolic mismatch in Tl-201 and BMIPP scintigraphic imaging in patients with chronic coronary artery disease and left ventricular dysfunction undergoing revascularization. | |
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MedLine Citation:
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PMID: 12043904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to assess the prognostic value of the amount of perfusion-metabolic mismatch in revascularized patients with left ventricular (LV) dysfunction by means of Thallium (Tl)-201 and BMIPP imaging. METHODS: Seventy-six patients with LV dysfunction and coronary artery disease underwent Tl-201 and BMIPP imaging. They were revascularized with either coronary artery bypass graft or balloon angioplasty and were entered into this study. To quantify the amount of perfusion-metabolic mismatch, SPECT images were displayed as polar maps and analyzed semiquantitatively. The patients were followed up for a mean period of 32 months for cardiac mortality and non-fatal cardiac events. Standard follow-up left ventriculography was performed 6 to 12 months after revascularization. RESULTS: Thirty-two patients exhibited a large amount of perfusion-metabolic mismatch (> 7 segments, group A), 28 patients had a small amount of perfusion-metabolic mismatch (2 to 6 segments, group B), and 16 patients were found to have no perfusion-metabolic mismatch (group C). Similar pre-revascularization LVEF of 35 +/- 5%, 34 +/- 8% and 36 +/- 6% increased to 45 +/- 8% (p < 0.0001), to 38 +/- 8% (p < 0.05), and to 36 +/- 3% (n.s.), respectively, after revascularization. The functional improvement after revascularization in group A was accompanied by a low rate of cardiac events during follow-up and better cardiac event free survival as judged by the Kaplan-Meier method (p < 0.05, vs. group B and C). CONCLUSION: In revascularized patients with severe LV dysfunction, the presence of a large amount of perfusionmetabolic mismatch evaluated by Tl-201 and BMIPP imaging identifies patients with the best prognosis. |
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Authors:
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Shigeru Fukuzawa; Shun Ozawa; Kazuhiro Shimada; Juji Sugioka; Masayuki Inagaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 16 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-06-04 Completed Date: 2002-12-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 109-15 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Funabashi Municipal Medical Center, Chiba, Japan. sf-fuku@qa2.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary Coronary Artery Bypass Coronary Artery Disease / metabolism, radionuclide imaging*, surgery Fatty Acids / diagnostic use* Female Humans Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use* Male Middle Aged Myocardial Revascularization Prognosis Radiopharmaceuticals / diagnostic use Thallium Radioisotopes / diagnostic use* Treatment Outcome Ventricular Dysfunction, Left / metabolism, radionuclide imaging*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 116754-87-1/iodofiltic acid |
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