Document Detail

Prognostic value of serum cholesterol level in Japanese patients with coronary artery disease.
MedLine Citation:
PMID:  9070969     Owner:  NLM     Status:  MEDLINE    
To determine the prognostic value of serum cholesterol level in Japanese patients with established coronary artery disease, we followed 330 consecutive patients with a left ventricular ejection fraction of > or = 50%. Over a period of 4.0 +/- 2.5 years, 53 patients (16%) experienced cardiac events. Multivariate analysis using Cox proportional hazard modeling revealed that obesity (risk ratio 4.3; p = 0.0001), the number of diseased vessels (risk ratio 1.9; p = 0.0001) and a serum cholesterol level > or = 220 mg/dl (risk ratio 2.3; p = 0.01) or > or = 200 mg/dl (risk ratio 2.1; p < 0.02) increase the risk of cardiac events. These results suggest that patients with established coronary artery disease and a serum cholesterol level > or = 200 mg/dl have a similar risk of experiencing a cardiac event as patients without left ventricular dysfunction and a serum cholesterol level > or = 220 mg/dl. Although the prevalence of coronary artery disease is low in Japan, the serum cholesterol level should be strictly controlled in subjects with established coronary artery disease to avoid future cardiac events.
T Takahashi; T Chikamori; Y Yonezawa; K Sugimoto; M Yamada; J Takata; T Ozawa; Y Doi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  61     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-27     Completed Date:  1997-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Department of Medicine and Geriatrics, Kochi Medical School, Japan.
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MeSH Terms
Cholesterol / blood*
Coronary Disease / blood*
Follow-Up Studies
Middle Aged
Risk Factors
Reg. No./Substance:

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