Document Detail

Prognostic value of reduced heart rate variability after myocardial infarction: clinical evaluation of a new analysis method.
MedLine Citation:
PMID:  1704246     Owner:  NLM     Status:  MEDLINE    
The relation between heart rate variability, measured from standard 24 hour electrocardiogram recordings in patients convalescent after a myocardial infarction, and the occurrence of sudden death and spontaneous, symptomatic, sustained ventricular tachycardia were assessed in a consecutive series of 177 patients admitted with acute myocardial infarction and surviving to 7 days. In addition to the analysis of heart rate variability, the occurrence of non-sustained arrhythmias on 24 hour electrocardiographic monitoring, and the results of clinical assessment, signal averaged electrocardiography and ejection fraction were analysed and were related to outcome. During a median of 16 months of follow up (range 10-30 months) there were 17 end point events (11 (6.2%) sudden deaths) and six (3.4%) episodes of sustained ventricular tachycardia. An index of the width of the frequency distribution curve for the duration of individual RR intervals was used to measure heart rate variability. This mean (SD) index was significantly smaller in those with end point events (16.8 (8.0)) than in those without events (29.0 (11.2)). The relative risk of the occurrence of an end point event in those with a heart rate variability index less than 25 was 7.0. Multivariate analysis showed that of all the variables examined a reduced heart rate variability index was the single most powerful predictor of end point events. Measurement of heart rate variability by this simple, automated, operator-independent method provided useful information on the arrhythmic propensity in patients convalescent after myocardial infarction.
T R Cripps; M Malik; T G Farrell; A J Camm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  65     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-03-15     Completed Date:  1991-03-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  14-9     Citation Subset:  AIM; IM    
Department of Cardiological Sciences, St George's Hospital Medical School, London.
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MeSH Terms
Cardiac Complexes, Premature / etiology
Death, Sudden
Electrocardiography / statistics & numerical data*
Follow-Up Studies
Heart Rate / physiology*
Middle Aged
Myocardial Infarction / complications,  physiopathology*
Risk Factors
Tachycardia / etiology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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