| Prognostic value of pulse-wave tissue Doppler parameters in patients with systolic heart failure. | |
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MedLine Citation:
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PMID: 18773996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim was to study the prognostic value of left ventricular (LV) function using pulse-wave tissue Doppler imaging (TDI) in an ordinary population with heart failure (HF). One hundred fifty-six patients hospitalized for HF and LV ejection fraction < or =40% were examined using conventional echocardiography and pulse-wave TDI for the assessment of longitudinal LV function. Mitral annular systolic and early diastolic (e') velocities were recorded from a mean of 4 annular sites from the apical 2- and 4-chamber views. Noninvasive LV filling pressure was calculated from the ratio between transmitral early inflow velocity (E) and e'. All patients were followed up for 2 years, and data from the National Registry of Deaths were collected. Mean LV ejection fraction was 24.7 +/- 7.2%. TDI recordings showed a mean mitral annular systolic velocity of 5.0 +/- 1.0 cm/s and e' velocity of 6.2 +/- 1.9 cm/s. E/e' ratio was 14.1 +/- 4.8. Thirty patients (19%) had atrial fibrillation. During follow-up, 27 patients (17%) died of a cardiovascular cause. Multivariate analysis showed that only E/e' ratio and age were predictors of cardiovascular mortality. A cut-off value for E/e' ratio >13 had sensitivity of 84% and specificity of 45% to identify patients who died within 2 years of cardiac reasons. In conclusion, in the acute stage of HF, E/e' ratio is a strong independent predictor of long-term cardiovascular mortality in an ordinary population with HF and systolic dysfunction. Systolic and diastolic velocities had no independent prognostic value. |
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Authors:
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Jens M Olson; Bassem A Samad; Mahbubul Alam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-05 |
Journal Detail:
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Title: The American journal of cardiology Volume: 102 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2008-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 722-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Karolinska Institute at South Hospital (Södersjukhuset), Stockholm, Sweden. jens.olsson@sodersjukhuset.se |
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Blood Flow Velocity / physiology Female Follow-Up Studies Heart Failure, Systolic / mortality*, physiopathology, ultrasonography* Heart Ventricles / ultrasonography* Humans Male Multivariate Analysis Prognosis Prospective Studies Sensitivity and Specificity Stroke Volume / physiology Ultrasonography, Doppler, Pulsed* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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