| Prognostic value of a proliferation index including MIB1 and argyrophilic nucleolar organizer regions proteins in node-negative breast cancer. | |
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MedLine Citation:
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PMID: 18455135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was designed to evaluate a cell proliferation marker, including the percentage of cycling cells (MIB1), and the duration of the cell cycle (assessed by argyrophilic nucleolar organizer regions proteins [AgNORs] measurement). STUDY DESIGN: We included 90 patients with invasive node-negative breast cancer. None received chemotherapy. With the help of a double-staining technique, a proliferation index (PI) was determined by multiplying the percentage of MIB1-positive cells by the mean area of the AgNORs present in those MIB1-positive cells. PI was evaluated for its impact on overall survival (OS) and disease-free survival (DFS). RESULTS: We demonstrated that PI was correlated to OS. For DFS, it conserved its high prognostic value only in univariate analysis. The global amount of AgNORs was more discriminative for DFS. CONCLUSION: PI and AgNOR quantification supplied additional prognosis information in node-negative patients, and we propose to integrate them in further studies. |
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Authors:
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Pascal Abboud; Marianne Lorenzato; Damien Joly; Christian Quereux; Philippe Birembaut; Dominique Ploton |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2008-05-02 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 199 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 146.e1-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Gynecology and Obstetrics, Hospital of Soissons, Soissons, France. pascal.abboud@ch-soissons.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, Nuclear / analysis* Breast Neoplasms / mortality*, physiopathology, surgery Cell Nucleus / chemistry* Cell Proliferation* Disease-Free Survival Female Humans Image Processing, Computer-Assisted Immunohistochemistry Ki-67 Antigen Multivariate Analysis Neoplasm Proteins Prognosis Ubiquitin-Protein Ligases / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Nuclear; 0/Ki-67 Antigen; 0/Neoplasm Proteins; 0/nucleolar organizer region associated proteins; EC 6.3.2.19/MIB1 protein, human; EC 6.3.2.19/Ubiquitin-Protein Ligases |
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