Document Detail

Prognostic value of positive pleural lavage in patients with lung cancer resection.
MedLine Citation:
PMID:  10355426     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite an early stage, lung cancer patients often have a poor survival, suggesting inaccurate staging. A pleural lavage demonstrating malignant cells at the time of operation may predict a poorer survival, particularly in patients with otherwise early disease. METHODS: Patients, with no preoperative evidence of pleural effusions and undergoing a surgical resection with curative intent, had a preresectional and postresectional lavage to be evaluated by cytology. RESULTS: Fourteen percent of patients with stage I disease had malignant cells in their preresectional lavage and had a significantly shorter survival than stage I patients with a negative lavage. Positivity of preresectional lavage was not correlated with nodal status, pleural or lymphatic involvement, or histologic findings. CONCLUSIONS: Preoperative pleural lavage should become a standard technique intraoperatively to better characterize and stage patients undergoing lung cancer resections. Patients with malignant cells in their preoperative lavage should be upstaged.
C M Dresler; C Fratelli; J Babb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  67     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-23     Completed Date:  1999-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1435-9     Citation Subset:  AIM; IM    
Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
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MeSH Terms
Adenocarcinoma / mortality,  pathology*,  surgery
Aged, 80 and over
Carcinoma, Squamous Cell / mortality,  pathology*,  surgery
Intraoperative Period
Lung Neoplasms / mortality,  pathology*,  surgery
Middle Aged
Neoplasm Staging
Pleural Effusion, Malignant / pathology*
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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