Document Detail


Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure.
MedLine Citation:
PMID:  15234408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study aimed to investigate the prognostic importance of plasma erythropoietin (EPO) levels in chronic heart failure (CHF) patients. BACKGROUND: Anemia is common and is associated with an impaired survival in patients with CHF. Erythropoietin is a hematopoietic growth factor, upregulated in anemic conditions. Little is known about the pathophysiology of anemia in CHF and the prognostic importance of plasma EPO levels in CHF patients. METHODS: In 74 patients with CHF (age, 61 +/- 2 years; left ventricular ejection fraction, 0.31 +/- 0.01; peak oxygen consumption, 19.1 +/- 0.6 [mean +/- SEM]) and in 15 control patients, hemoglobin levels and plasma concentrations of EPO and brain natriuretic peptide were measured. RESULTS: During a mean follow-up of 3.0 years (range, 2.3 to 5.3 years), 22 patients (30%) died. Anemia was present in 24% of the patients. Multivariate analysis showed that plasma EPO (p = 0.026) and hemoglobin levels (p = 0.005) were independent predictors of survival in this CHF population. We observed only a mild inverse correlation between the logarithm of EPO and hemoglobin levels (r2 = 0.08, p = 0.02) in CHF patients, whereas the control group showed a clear significant inverse correlation (r2 = 0.44, p = 0.007). CONCLUSIONS: Elevated plasma EPO levels are associated with an impaired prognosis independent of hemoglobin levels and other established markers of CHF severity. Furthermore, in the CHF patients, EPO levels poorly correlate with the hemoglobin levels, in contrast with the control group.
Authors:
Peter van der Meer; Adriaan A Voors; Erik Lipsic; Tom D J Smilde; Wiek H van Gilst; Dirk J van Veldhuisen
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  44     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-05     Completed Date:  2004-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands. p.van.der.meer@thorax.azg.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Chronic Disease
Erythropoietin / blood*,  diagnostic use*
Female
Follow-Up Studies
Heart Failure / blood,  diagnosis*,  mortality*
Hemoglobins / metabolism
Humans
Male
Middle Aged
Natriuretic Peptide, Brain / blood
Netherlands
Prognosis
Retrospective Studies
Severity of Illness Index
Statistics as Topic
Survival Analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Hemoglobins; 11096-26-7/Erythropoietin; 114471-18-0/Natriuretic Peptide, Brain

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