Document Detail


Prognostic value of periodic electroencephalographic discharges for neurological patients with profound disturbances of consciousness.
MedLine Citation:
PMID:  22809812     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine if periodic EEG discharges (PDs) predict poor outcome and development of epilepsy in patients with acute brain illnesses irrespective of underlying cerebral pathology.
METHODS: In case-control study we retrospectively analyzed outcome of 102 patients with PDs and 102 age-, gender- and etiology matched controls without PDs.
RESULTS: Of cases, 46.1% had lateralized PDs (LPDs), 3.9% bilateral PDs (BIPDs), 15.7% generalized PDs (GPDs) and 34.3% had combinations thereof.
ETIOLOGY: Stroke was most common cause of LPDs (53%), cardiac arrest of GPDs (10.5%), previous stroke, CNS infection, anoxia and metabolic encephalopathy all caused 1 case of BIPDs.
OUTCOME: Mortality rate and acquired disability was significantly higher in patients with PDs than in controls, odds ratio (OR) 2.5, 95% CI 1.43-4.40 (p = 0.001). Patients with PDs without superimposed EEG activity had worse outcome than patients with superimposed EEG activity. Tardive epilepsy: Patients with LPDs associated with fast superimposed EEG activity (LPDs-plus) had higher risk for tardive epilepsy than patients with LPDs alone (p = 0.034).
CONCLUSION: PDs predicted poor functional outcome and patients with LPDs-plus had higher risk for later development of epilepsy.
SIGNIFICANCE: Detailed evaluation of PDs provided valuable prognostic information in neurological patients with disturbed consciousness.
Authors:
Gyrithe L Pedersen; Stine B Rasmussen; Jesper Gyllenborg; Krisztina Benedek; Martin Lauritzen
Publication Detail:
Type:  Journal Article     Date:  2012-07-17
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  124     ISSN:  1872-8952     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-02-12     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  44-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anticonvulsants / pharmacology,  therapeutic use
Cohort Studies
Consciousness Disorders / classification,  etiology,  physiopathology*
Electroencephalography*
Epilepsy / drug therapy,  physiopathology
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Nervous System Diseases / complications,  physiopathology*
Neuroimaging
Prognosis
Risk Factors
Survivors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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