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Prognostic value of periodic electroencephalographic discharges for neurological patients with profound disturbances of consciousness.
MedLine Citation:
PMID:  22809812     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To examine if periodic EEG discharges (PDs) predict poor outcome and development of epilepsy in patients with acute brain illnesses irrespective of underlying cerebral pathology. METHODS: In case-control study we retrospectively analyzed outcome of 102 patients with PDs and 102 age-, gender- and etiology matched controls without PDs. RESULTS: Of cases, 46.1% had lateralized PDs (LPDs), 3.9% bilateral PDs (BIPDs), 15.7% generalized PDs (GPDs) and 34.3% had combinations thereof. Etiology: Stroke was most common cause of LPDs (53%), cardiac arrest of GPDs (10.5%), previous stroke, CNS infection, anoxia and metabolic encephalopathy all caused 1 case of BIPDs. Outcome: Mortality rate and acquired disability was significantly higher in patients with PDs than in controls, odds ratio (OR) 2.5, 95% CI 1.43-4.40 (p=0.001). Patients with PDs without superimposed EEG activity had worse outcome than patients with superimposed EEG activity. Tardive epilepsy: Patients with LPDs associated with fast superimposed EEG activity (LPDs-plus) had higher risk for tardive epilepsy than patients with LPDs alone (p=0.034). CONCLUSION: PDs predicted poor functional outcome and patients with LPDs-plus had higher risk for later development of epilepsy. SIGNIFICANCE: Detailed evaluation of PDs provided valuable prognostic information in neurological patients with disturbed consciousness.
Authors:
Gyrithe L Pedersen; Stine B Rasmussen; Jesper Gyllenborg; Krisztina Benedek; Martin Lauritzen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-16
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  -     ISSN:  1872-8952     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Clinical Neurophysiology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark; Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen N, Denmark; Centre for Healthy Aging, University of Copenhagen, Copenhagen N, Denmark.
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