| Prognostic value of osteoprotegerin in chronic heart failure: The GISSI-HF trial. | |
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MedLine Citation:
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PMID: 20691834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Circulating levels of osteoprotegerin (OPG), a member of the tumor necrosis factor receptor superfamily, is predictive of death and hospitalization for heart failure after acute coronary syndrome. The association between OPG and outcome in patients with chronic heart failure (CHF) is unknown. METHODS: Plasma OPG levels at baseline were assessed in 1,229 patients with CHF recruited from 51 clinical centers and included in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure (GISSI-HF) trial. Patients were randomized to n-3 polyunsaturated fatty acids (1 g/d) or rosuvastatin (10 mg/d) versus placebo. Osteoprotegerin was analyzed by enzyme-linked immunosorbent assay. The association between OPG and outcome was assessed by Cox proportional hazards regression models. RESULTS: During a median follow-up time of 3.9 years, 332 patients died; and 791 patients died or were hospitalized because of cardiovascular causes. By univariate analysis, baseline OPG levels were strongly associated with the incidence of death (hazard ratio {HR} [95% CI] 1.53 [1.40-1.67] per 1-SD increase in log OPG). After adjustment for conventional risk markers, OPG remained a significant predictor of death (HR [95% CI] 1.20 [1.06-1.35], P < .001). Similar findings were observed for the composite end point (HR [95% CI] 1.34 [1.07-1.69], P = .012). CONCLUSION: In patients with CHF, OPG is associated with the incidence of death independently of conventional cardiovascular risk factors. |
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Authors:
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Ragnhild Røysland; Serge Masson; Torbjørn Omland; Valentina Milani; Mette Bjerre; Allan Flyvbjerg; Giuseppe Di Tano; Gianfranco Misuraca; Aldo P Maggioni; Gianni Tognoni; Luigi Tavazzi; Roberto Latini; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: American heart journal Volume: 160 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 286-93 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Medicine, Akershus University Hospital, Lørenskog, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Fluorobenzenes / therapeutic use Fluoroimmunoassay Heart Failure / blood*, drug therapy, mortality* Hospitalization / statistics & numerical data Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Italy Male Middle Aged Osteoprotegerin Prognosis Proportional Hazards Models Pyrimidines / therapeutic use Sulfonamides / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Osteoprotegerin; 0/Pyrimidines; 0/Sulfonamides; 287714-41-4/rosuvastatin |
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