Document Detail

Prognostic value of neutrophils and NK cells in bronchoalveolar lavage of sarcoidosis.
MedLine Citation:
PMID:  16977633     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Not all the patients with sarcoidosis need pharmacological therapy, and the decision to start therapy is based mainly on clinical conditions. The aim of this study was to evaluate the prognostic value of the leukocyte and lymphocyte subpopulations in the bronchoalveolar lavage fluid from these patients. METHODS: Thirty-three nonsmoking patients with sarcoidosis were included and classified based on the presence of Löfgren's syndrome (n = 11), the radiological stage (12 at Stage I, 17 at Stage II, and 4 at Stage III), and their follow-up. Differential leukocyte subsets and the lymphocyte subpopulations were determined by flow cytometry. RESULTS: The percentage of neutrophils was lower in patients with Löfgren's syndrome (P = 0.038) and in patients at Stage I (P = 0.002). Patients with a poor outcome had a higher percentage of neutrophils (P = 0.004) and NK cells (P = 0.023) than those with a stable disease. Finally, a higher percentage of NK cells was found in those patients who needed a steroid treatment (P = 0.012). CONCLUSIONS: Increased percentages of neutrophils and NK cells in the bronchoalveolar lavage fluid from patients with sarcoidosis are associated with a poor outcome and a higher probability to need steroids treatment. The percentage of neutrophils was also lower in patients with Löfgren's syndrome.
Pablo Tutor-Ureta; María J Citores; Raquel Castejón; Susana Mellor-Pita; Miguel Yebra-Bango; Yolanda Romero; Juan A Vargas
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytometry. Part B, Clinical cytometry     Volume:  70     ISSN:  1552-4949     ISO Abbreviation:  Cytometry B Clin Cytom     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-17     Completed Date:  2006-12-12     Revised Date:  2009-12-11    
Medline Journal Info:
Nlm Unique ID:  101235690     Medline TA:  Cytometry B Clin Cytom     Country:  United States    
Other Details:
Languages:  eng     Pagination:  416-22     Citation Subset:  IM    
Copyright Information:
Copyright 2006 International Society for Analytical Cytology.
Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro, Departamento de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.
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MeSH Terms
Bronchoalveolar Lavage Fluid / cytology,  immunology*
Flow Cytometry / methods
Follow-Up Studies
Killer Cells, Natural / pathology*
Middle Aged
Neutrophils / pathology*
Sarcoidosis, Pulmonary / diagnosis*,  drug therapy,  pathology
Sensitivity and Specificity
Steroids / therapeutic use
Reg. No./Substance:

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