Document Detail

Prognostic value of myocardial perfusion imaging in patients with high exercise tolerance.
MedLine Citation:
PMID:  10027807     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although high exercise tolerance is associated with an excellent prognosis, the significance of abnormal myocardial perfusion imaging (MPI) in patients with high exercise tolerance has not been established. This study retrospectively compares the utility of MPI and exercise ECG (EECG) in these patients. METHODS AND RESULTS: Of 388 consecutive patients who underwent exercise MPI and reached at least Bruce stage IV, 157 (40.5%) had abnormal results and 231 (59.5%) had normal results. Follow-up was performed at 18+/-2.7 months. Adverse events, including revascularization, myocardial infarction, and cardiac death, occurred in 40 patients. Nineteen patients had revascularization related to the MPI results or the patient's condition at the time of MPI and were not included in further analysis. Seventeen patients (12.2%) with abnormal MPI and 4 (1.7%) with normal MPI had adverse cardiac events (P<0.001). Cox proportional-hazards regression analysis showed that MPI was an excellent predictor of cardiac events (global chi2=13.2; P<0.001; relative risk=8; 95% CI=3 to 23) but EECG had no predictive power (global chi2=0.05; P=0.8; relative risk=1; 95% CI=0.4 to 3.0). The addition of Duke's treadmill score risk categories did not improve the predictive power of EECG (global chi2=0.17). The predictive power of the combination of EECG (including Duke score categories) and MPI was no better than that of MPI alone (global chi2=13.5). CONCLUSIONS: Unlike EECG, MPI is an excellent prognostic indicator for adverse cardiac events in patients with known or suspected CAD and high exercise tolerance.
S N Chatziioannou; W H Moore; P V Ford; R E Fisher; V V Lee; C Alfaro-Franco; R D Dhekne
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Circulation     Volume:  99     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1999 Feb 
Date Detail:
Created Date:  2000-06-29     Completed Date:  2000-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  867-72     Citation Subset:  AIM; IM    
Department of Radiology, Baylor College of Medicine, St. Luke's Episcopal Hospital/Texas Heart Institute, Houston 77030, USA.
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MeSH Terms
Aged, 80 and over
Coronary Circulation*
Coronary Disease / diagnosis,  physiopathology,  radionuclide imaging
Exercise / physiology*
Exercise Test
Middle Aged
Physical Endurance*
Predictive Value of Tests
Tomography, Emission-Computed, Single-Photon*

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