| Prognostic value of "monosomal karyotype" in comparison to "complex aberrant karyotype" in acute myeloid leukemia: study on 824 cases with aberrant karyotype. | |
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MedLine Citation:
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PMID: 22207733 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In acute myeloid leukemia (AML) the subset with complex karyotype (CK) is traditionally regarded as the worst prognostic group. However, ≥3, ≥4 or ≥5 abnormalities have been variably used for its definition. Recently, "monosomal karyotype" (MSK) was suggested to indicate an even inferior outcome. We tested which definition fits best to identify the most unfavorable subgroup. After excluding patients with t(15;17)/PML-RARA, t(8;21)/RUNX1-RUNX1T1, inv(16)/t(16;16)/CBFB-MYH11 and normal karyotype 824 AML patients with cytogenetic abnormalities were analyzed. Patients with MSK or CK defined as ≥3, ≥4 or ≥5 abnormalities showed an inferior OS compared to the respective remaining patients not fulfilling these criteria (for all p<0.001). Hazard ratios were 1.93, 1.68, 1.94, and 1.92. CK≥4 as a single parameter identified the largest proportion of patients with very poor risk. However, combining CK≥4 and MSK detected an even larger number of patients with very unfavorable outcome (261/824, 31.7%). |
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Authors:
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Claudia Haferlach; Tamara Alpermann; Susanne Schnittger; Wolfgang Kern; Jörg Chromik; Christoph Schmid; Hermann Josef Pielken; Karl-Anton Kreuzer; Heinz-Gert Höffkes; Torsten Haferlach |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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MLL Munich Leukemia Laboratory, Munich, Germany; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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