Document Detail


Prognostic value of mitral regurgitation assessment during exercise echocardiography in patients with left ventricular dysfunction: a follow-up study of 1.7 +/- 1.5 years.
MedLine Citation:
PMID:  17241820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The value of exercise echocardiography (EE) over resting echocardiography when this last incorporates information on mitral regurgitation (MR) is only partially known. Furthermore, limited data exist regarding the value of MR worsening during exercise in patients with left ventricular (LV) dysfunction. We investigate whether EE has incremental value over a resting echo-Doppler study; and whether post-exercise MR increments the value of EE for predicting outcome in patients with LV dysfunction. METHODS AND RESULTS: Three hundred and twenty-three consecutive patients with LV dysfunction (LV ejection fraction < or =45%) referred for EE were followed for 1.7 +/- 1.5 years. There were 43 hard events (myocardial infarction in 9 and cardiac death in 34). Resting MR, peak heart rate x blood pressure, and number of involved territories at exercise were independently associated to hard events (incremental P-value of EE =0.02). Independent variables associated to cardiac death were resting MR, peak heart rate x blood pressure, peak wall motion score index, and MR worsening (incremental P-value of MR worsening = 0.04). CONCLUSIONS: EE maintains its prognostic value over resting echocardiography even when this last incorporates information on MR. Exercise-induced MR worsening has independent prognostic value for cardiac death in patients with LV dysfunction.
Authors:
Jesús Peteiro; Isaac Bendayan; Javier Mariñas; Rosa Campos; Beatriz Bouzas; Alfonso Castro-Beiras
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  9     ISSN:  1532-2114     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-02-12     Completed Date:  2008-06-03     Revised Date:  2008-07-29    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  18-25     Citation Subset:  IM    
Affiliation:
Unit of Echocardiography, Juan Canalejo Hospital, University of A Coruña, A Coruña, Spain. peteiro@canalejo.org
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MeSH Terms
Descriptor/Qualifier:
Aged
Chi-Square Distribution
Echocardiography, Doppler, Color*
Echocardiography, Stress*
Exercise Test
Female
Follow-Up Studies
Humans
Male
Mitral Valve Insufficiency / physiopathology*,  therapy,  ultrasonography*
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Survival Analysis
Ventricular Dysfunction, Left / physiopathology*,  therapy,  ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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