| Prognostic value of minimal blood flow restoration in patients with acute myocardial infarction after reperfusion therapy. | |
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MedLine Citation:
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PMID: 19763661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The prognostic impact of low-flow reperfusion after percutaneous coronary intervention (PCI) in patients with ST-segment elevation acute myocardial infarction (STEMI) is unknown. The aim of the study was to investigate the impact of low-flow reperfusion after PCI in patients with STEMI. METHODS: This study included 1,761 patients with STEMI with a baseline thrombolysis in myocardial infarction (TIMI) flow grade 0 and no collateral circulation to the infarcted region before primary PCI. The primary outcome was 1-year mortality. RESULTS: At the end of PCI procedure there were 115 patients with post-PCI TIMI flow grade 0; 57 patients with TIMI flow grade 1; 218 patients with TIMI flow grade 2; and 1,371 patients with TIMI flow grade 3. At 1 year there were 36 deaths in patients with TIMI grade 0; 28 deaths in patients with TIMI grade 1; 42 deaths in patients with TIMI grade 2; and 162 deaths in patients with TIMI grade 3 [estimates of mortality 32.6, 49.1, 19.6 and 12.1%, respectively; odds ratio (OR) = 1.76, 95% CI 1.08-2.86, P = 0.02, for TIMI flow grade 1 vs. TIMI flow grade 0]. The Cox proportional hazards model identified post-PCI TIMI flow grade as an independent predictor of 1-year mortality [hazard ratio (HR) = 1.99, 95% CI 1.17-3.28; P = 0.01 for TIMI flow grade 1 vs. TIMI flow grade 0]. CONCLUSIONS: Patients with STEMI with totally occluded infarct-related arteries and no collateral blood flow to the infarcted region show a greater mortality with post-PCI TIMI flow grade 1 than TIMI flow grade 0. |
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Authors:
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Gjin Ndrepepa; Dritan Keta; Stefanie Schulz; Robert A Byrne; Julinda Mehilli; J?rgen Pache; Melchior Seyfarth; Albert Sch?mig; Adnan Kastrati |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2009-09-10 |
Journal Detail:
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Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: 99 ISSN: 1861-0692 ISO Abbreviation: Clin Res Cardiol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-22 Completed Date: 2010-04-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
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Deutsches Herzzentrum, Technische Universit?t, Lazarettstr. 36, 80636, Munich, Germany. ndrepepa@dhm.mhn.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary / methods* Female Follow-Up Studies Humans Male Middle Aged Myocardial Infarction / mortality, physiopathology, therapy* Myocardial Reperfusion / mortality* Predictive Value of Tests Prognosis Proportional Hazards Models Thrombolytic Therapy / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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