Document Detail


Prognostic value and long-term variation of high sensitivity troponin T in clinically stable haemodialysis patients.
MedLine Citation:
PMID:  25228425     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: To provide data on the long-term prognostic relevance and variation of high sensitivity troponin T (hsTnT) in haemodialysis patients.
METHODS: In 238 stable, asymptomatic haemodialysis patients from a single-centre hsTnT was measured at baseline, 18 and 22 months and outcomes assessed for 24 months.
RESULTS: Baseline hsTnT was a significant predictor of all cause (+10ng/l, HR 1.017, 95%CI 1.011-1.023, p<0.0001) and cardiovascular death (HR 1.02, 95%CI 1.013-1.0026, p<0.0001). HsTnT>140ng/L was a strong predictor of cardiovascular mortality (HR 8.51, 95%CI 1.907-38.032; p<0.0001). HsTnT increased by >50% in less than one-third of patients, and doubled in only 10% of patients, during 18 and 22 months follow up.
CONCLUSION: In clinically stable hemodialysis patients, higher hsTnT was associated with both total and CV mortality. In most patients variation in levels of hsTnT between 18 and 22 months was <50%, and on average the increase in hsTnT was small.
Authors:
Stefanie Honneger; David Semple; Karishma Sidhu; Ralph Stewart; Helen Pilmore
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Publication Detail:
Type:  Journal Article     Date:  2014-09-12
Journal Detail:
Title:  The New Zealand medical journal     Volume:  127     ISSN:  1175-8716     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  2014  
Date Detail:
Created Date:  2014-09-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  97-109     Citation Subset:  IM    
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