| Prognostic value of interleukin-6 during a 3-year follow-up in patients with acute ST-segment elevation myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 19784814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Accumulating evidence suggests that inflammation plays an essential role in the pathogenesis of atherosclerosis. This recognition has stimulated the evaluation of different inflammatory markers as potential predictors of cardiovascular risk. However, the existing data are limited and controversial. This study was designed to simultaneously measure serum levels of interleukin-6 (IL-6), soluble CD40 ligand (sCD40L), metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with acute ST segment elevation myocardial infarction (STEMI) and to evaluate their ability to predict prognosis. A prospective cohort study was conducted with 263 patients with first STEMI who were admitted to our institute within 6 h of symptoms onset. Clinical data were recorded and serum admission levels of IL-6, sCD40L, MMP-9, and TIMP-1 were measured by sandwich enzyme-linked immunosorbent assay. The patients were then followed prospectively for the occurrence of cardiovascular mortality for 3 years. Follow-up information was available for 228 patients (86.7%) from the 263 STEMI patients; 34 patients died from cardiovascular causes during the 3-year follow-up period. Kaplan-Meier plots demonstrated a significant increase in cardiovascular mortality with increasing IL-6 levels (chi(2) = 14.13, P = 0.0002, by log-rank test). Logistic regression analysis revealed that IL-6 was an independent predictor for cardiovascular mortality. The present study indicates that elevated admission level of IL-6 could provide valuable information for long-term risk stratification in patients with STEMI. |
| | |
Authors:
|
Jing Tan; Qi Hua; Jing Li; Zhenxing Fan |
Related Documents
:
|
17404864 - Clinical features, serum interleukin-6, and interferon-gamma levels of 34 turkish patie... 7743304 - Are serum concentrations of nitric oxide metabolites useful for predicting the clinical... 7778854 - Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. 16843904 - An evaluation of insulin-like growth factor-1 as an indicator of nutritional status. 2217314 - Circadian periodicity of the time of onset of acute lower gastrointestinal bleeding. 18377434 - Nickel allergy in interatrial shunt device-based closure patients. |
Publication Detail:
|
Type: Journal Article Date: 2009-09-27 |
Journal Detail:
|
Title: Heart and vessels Volume: 24 ISSN: 1615-2573 ISO Abbreviation: Heart Vessels Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-09-28 Completed Date: 2009-12-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
|
Languages: eng Pagination: 329-34 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Biological Markers / blood CD40 Ligand / blood Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Inflammation Mediators / blood* Interleukin-6 / blood* Kaplan-Meiers Estimate Logistic Models Male Matrix Metalloproteinase 9 / blood Middle Aged Myocardial Infarction / immunology, mortality, therapy* Patient Admission Predictive Value of Tests Prospective Studies Risk Assessment Risk Factors Time Factors Tissue Inhibitor of Metalloproteinase-1 / blood Treatment Outcome Up-Regulation |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 0/Tissue Inhibitor of Metalloproteinase-1; 147205-72-9/CD40 Ligand; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Meta-analysis of randomized, controlled clinical trials in angiogenesis: gene and cell therapy in pe...
Next Document: Effect of balloon inflation time on expansion of sirolimus-eluting stent.