| Prognostic value of initial echocardiographic features in patients with tuberculous pericarditis. | |
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MedLine Citation:
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PMID: 20830251 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Tuberculous (TB) pericarditis is a major cause of constrictive pericarditis requiring pericardiectomy. We sought to determine initial prognostic factors in patients with TB pericarditis. SUBJECTS AND METHODS: We evaluated initial presentation and clinical outcomes (mean follow-up 32±27 months) in 60 consecutive patients newly diagnosed with TB pericarditis. RESULTS: Initial presentations were pericardial effusion (PE), effusive-constrictive pericarditis, and constrictive pericarditis in 45 (75%), 9 (15%), and 6 (10%) patients, respectively. Of the 54 patients without initial constrictive pericarditis, 32 (59%) showed echogenic materials in PE, including frond-like exudative coating and fibrinous strands. These patients had a longer disease duration before diagnosis, were initially more symptomatic, in a more advanced state, showed more persistent pericardial constrictions (38% vs. 0%, p<0.001) despite anti-TB medications, and tended to require pericardiectomy more often (19% vs. 0%, p=0.07, p<0.05 by Kaplan-Meier). All patients with effusive-constrictive pericarditis showed echogenic PE. Of the 60 total patients, 10 (17%) underwent pericardiectomies during follow-up. All of these patients showed initial pericardial constrictions, whereas no patient without initial pericardial constriction underwent pericardiectomy (p<0.001). Seven patients showed transient pericardial constrictions that resolved without pericardiectomy. CONCLUSION: Initial pericardial constriction and echogenic PE are poor prognostic signs for persistent pericardial constriction and pericardiectomy in patients with newly diagnosed TB pericarditis. These results suggest that early diagnosis and prompt anti-TB medication may be critical. |
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Authors:
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Hyung Oh Choi; Jong-Min Song; Tae Sun Shim; Sang-Hyun Kim; In-Hyun Jung; Duk-Hyun Kang; Jae-Kwan Song |
Publication Detail:
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Type: Journal Article Date: 2010-08-31 |
Journal Detail:
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Title: Korean circulation journal Volume: 40 ISSN: 1738-5555 ISO Abbreviation: Korean Circ J Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101247141 Medline TA: Korean Circ J Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 377-86 Citation Subset: - |
Affiliation:
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Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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