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Prognostic value of initial antithrombin levels in neonatal sepsis.
MedLine Citation:
PMID:  17827633     Owner:  NLM     Status:  In-Process    
OBJECTIVES: We determined whether initial antithrombin (AT) levels help in diagnosis and prognosis of neonatal sepsis. METHODS: Sepsis was diagnosed according to clinical and laboratory findings and positive culture results in 34 of the 54 newborns who presented to the hospital with suspected sepsis. Between AT levels and hematological parameters (fibrinogen levels, prothrombin time (PT), activated partial thromboplastin time (aPTT) and liver function tests), these were correlated each other and with outcome of the babies. RESULTS: Initial AT and fibrinogen levels were significantly lower in newborns with sepsis compared to control (P < 0.05). Initial AT levels were lower in the ones who developed disseminated intravascular coagulation (DIC) compared to those without DIC (P < 0.05). Initial AT levels were significantly lower in newborns who died as compared to survivors (P < 0.05). Sensitivity of AT was highest at 15 mg/dL for prognosis in neonatal sepsis (sensitivity:92.3%, specificity:61.9%, positive predictive value : 61.9 %; negative predictive value: 61.9%;). CONCLUSION: Lower initial AT levels in neonatal sepsis are associated with a severe disease and increased mortality. It may be useful in predicting clinical outcome in neonatal sepsis.
Betul Ersoy; Hakan Nehir; Serdar Altinoz; Ozge Yilmaz; Pinar Erbay Dundar; Aysel Aydogan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  44     ISSN:  0974-7559     ISO Abbreviation:  Indian Pediatr     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  581-4     Citation Subset:  IM    
Department of Pediatrics, Celal Bayar University, School of Medicine, Manisa, Turkey.
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