Document Detail

Prognostic value of FEV1/FEV6 in elderly people*.
MedLine Citation:
PMID:  20969726     Owner:  NLM     Status:  In-Data-Review    
Background:  The ratio of forced expiratory volume in 1 s and forced expiratory volume in 6 s (FEV1/FEV6) has been proposed as an alternative for FEV1/forced vital capacity (FVC) to diagnose obstructive diseases with less effort during spirometry; however, its prognostic value is unknown. We evaluated whether FEV1/FEV6 is a significant predictor of mortality in elderly subjects and compared its prognostic value with that of FEV1/FVC and FEV1. Methods:  One thousand nine hundred and seventy-one subjects, aged >65 years, participated in the population-based SA.R.A. study. During the baseline exam, a multidimensional assessment included spirometry. Vital status was determined during 6 years of follow-up. Association of all-cause, cardio-pulmonary (CP) and non-CP mortality with a low FEV1/FEV6, FEV1/FVC and FEV1 was evaluated. Results:  Among subjects with both survival data and acceptable spirometry including FEV6, all-cause unadjusted mortality rates were 7·00 and 2·46 per 100 person-years in subjects with FEV1/FEV6 less than and greater than or equal to lower limit of normal (LLN), respectively (mortality rate ratio: 2·84, 95%CI: 2·12-3·84). After adjustment for age, gender, FVC, smoke exposure and main comorbidities, the risk of all-cause mortality remained significantly increased in subjects with FEV1/FEV6 < LLN [hazard ratio (HR): 1·87, 95%CI: 1·35-2·58] as well as in subjects with FEV1/FVC < LLN (HR: 2·01, 95%CI: 1·51-2·90) and FEV1 < LLN (HR: 2·17, 95%CI: 1·32-3·57). Similar results were found for CP mortality, but not for non-CP mortality. Conclusions:  A low FEV1/FEV6 is a significant predictor of mortality in older individuals. Its prognostic value is comparable to that of a low FEV1/FVC and FEV1.
Claudio Sorino; Duane Sherrill; Stefano Guerra; Paul Enright; Claudio Pedone; Giuseppe Augugliaro; Nicola Scichilone; Salvatore Battaglia; Raffaele Antonelli-Incalzi; Vincenzo Bellia
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Publication Detail:
Type:  Journal Article     Date:  2010-10-24
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  31     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Clinical Physiology and Functional Imaging © 2010 Scandinavian Society of Clinical Physiology and Nuclear Medicine.
Department of Medicine, Pneumology, Physiology and Human Nutrition, University of Palermo, Palermo, Italy Mel and Enid Zuckerman College of Public Health, University of Arizona Arizona Respiratory Center, University of Arizona, Tucson, Arizona Centre for Research in Environmental Epidemiology, IMIM-Hospital del Mar, CIBERESP, Barcelona, Spain Chair of Geriatrics, University Campus Bio-Medico, Roma, Italy.
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