Document Detail

Prognostic value of heart rate variability in patients awaiting cardiac transplantation.
MedLine Citation:
PMID:  1279628     Owner:  NLM     Status:  MEDLINE    
Time and frequency domain parameters of heart rate variability (HRV) were determined in patients with severe endstage heart failure awaiting cardiac transplantation (HTX). These parameters were then correlated with mortality to investigate the performance of HRV in discriminating between groups with high and low risk of death. The standard deviation of five consecutive RR intervals (SDANN) was found to be the parameter with the greatest sensitivity (90%) and specificity (91%). Patients with SDANN values of < 55 msec had a twenty-fold increased risk of death (90% confidence limits: 4-118, P < 0.001). The results furthermore suggest that measurements of HRV are superior to other prognostic markers such as left ventricular ejection fraction, pulmonary artery wedge pressure, cardiac index, and serum sodium levels. We conclude that HRV is a powerful, noninvasive tool to assess the risk of death in candidates for HTX. HRV measurements can therefore be used as a supplement to other markers of risk to determine the optimal therapeutic strategy in patients with severe congestive heart failure.
T Binder; B Frey; G Porenta; G Heinz; M Wutte; G Kreiner; H Gössinger; H Schmidinger; R Pacher; H Weber
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  15     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-16     Completed Date:  1992-12-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2215-20     Citation Subset:  IM    
Allgemeines Krankenhaus Wien (AKH), Klinik für Innere Medizin II, Abt für Kardiologie, Vienna, Austria.
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MeSH Terms
Electrocardiography, Ambulatory / methods*
Fourier Analysis
Heart Failure / diagnosis,  mortality*
Heart Rate / physiology*
Heart Transplantation*
Middle Aged
Predictive Value of Tests
Risk Factors
Sensitivity and Specificity
Signal Processing, Computer-Assisted*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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