Document Detail

Prognostic value of frontal functional neuroimaging in late-onset severe major depression.
MedLine Citation:
PMID:  15056574     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is growing evidence of a relationship between frontal neuroimaging and neuropsychological abnormalities and the physiopathology and course of late-onset major depression. AIMS: To assess acute antidepressant response in late-onset major depression in relation to baseline frontal perfusion ratios. METHOD: A 99mTc HMPAO single photon emission computed tomographic brain scan was performed in medication-free patients with late-onset major depression, who were then included in a 12-week antidepressant treatment regimen. Logistic regression was used to define a predictive model of non-remission. RESULTS: A total of 47 patients completed the study, 34 of whom were classed as remitters and 13 as non-remitters. The variable left anterior fronto-cerebellar perfusion ratio had a global predictive power of 87%. Analysing this variable together with the baseline variables age of onset and duration of index episode, the predictive power of the model rose to 94%. CONCLUSIONS: Our study suggests that a specific frontal functioning could predict the acute antidepressant response in late-onset severe major depression.
Victor Navarro; Cristóbal Gastó; Francisco Lomeña; Xavier Torres; José J Mateos; María J Portella; Guillem Masana; Teodoro Marcos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  184     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  306-11     Citation Subset:  IM    
Clinical Institute of Psychiatry and Psychology, Hospital Clinic, Barcelona, Spain.
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MeSH Terms
Age of Onset
Aged, 80 and over
Antidepressive Agents / therapeutic use
Cerebrovascular Circulation
Depressive Disorder / drug therapy,  physiopathology,  radionuclide imaging*
Frontal Lobe / blood supply,  radionuclide imaging*
Logistic Models
Middle Aged
Predictive Value of Tests
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Exametazime / diagnostic use
Tomography, Emission-Computed, Single-Photon / methods
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents; 0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

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