| Prognostic value of frontal functional neuroimaging in late-onset severe major depression. | |
MedLine Citation:
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PMID: 15056574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is growing evidence of a relationship between frontal neuroimaging and neuropsychological abnormalities and the physiopathology and course of late-onset major depression. AIMS: To assess acute antidepressant response in late-onset major depression in relation to baseline frontal perfusion ratios. METHOD: A 99mTc HMPAO single photon emission computed tomographic brain scan was performed in medication-free patients with late-onset major depression, who were then included in a 12-week antidepressant treatment regimen. Logistic regression was used to define a predictive model of non-remission. RESULTS: A total of 47 patients completed the study, 34 of whom were classed as remitters and 13 as non-remitters. The variable left anterior fronto-cerebellar perfusion ratio had a global predictive power of 87%. Analysing this variable together with the baseline variables age of onset and duration of index episode, the predictive power of the model rose to 94%. CONCLUSIONS: Our study suggests that a specific frontal functioning could predict the acute antidepressant response in late-onset severe major depression. |
Authors:
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Victor Navarro; Cristóbal Gastó; Francisco Lomeña; Xavier Torres; José J Mateos; María J Portella; Guillem Masana; Teodoro Marcos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 184 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-01 Completed Date: 2004-05-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 306-11 Citation Subset: IM |
Affiliation:
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Clinical Institute of Psychiatry and Psychology, Hospital Clinic, Barcelona, Spain. 30739vno@comb.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Aged Aged, 80 and over Antidepressive Agents / therapeutic use Cerebrovascular Circulation Depressive Disorder / drug therapy, physiopathology, radionuclide imaging* Female Frontal Lobe / blood supply, radionuclide imaging* Humans Logistic Models Male Middle Aged Predictive Value of Tests Prognosis Radiopharmaceuticals / diagnostic use Technetium Tc 99m Exametazime / diagnostic use Tomography, Emission-Computed, Single-Photon / methods Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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