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Prognostic value of extravascular lung water index in critically ill children with acute respiratory failure.
MedLine Citation:
PMID:  20878387     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: In critically ill adults, a reduction in the extravascular lung water index (EVLWi) decreases time on mechanical ventilation and improves survival. The purpose of this study is to assess the prognostic value of EVLWi in critically ill children with acute respiratory failure and investigate its relationships with PaO(2), PaO(2)/FiO(2) ratio, A-aDO(2), oxygenation index (OI), mean airway pressure, cardiac index, pulmonary permeability, and percent fluid overload.
METHODS: Twenty-seven children admitted to PICU with acute respiratory failure received volumetric hemodynamic and blood gas monitoring following initial stabilization and every 4 h thereafter, until discharge from PICU or death. All patients are grouped in two categories: nonsurvivors and survivors.
RESULTS: Children with a fatal outcome had higher values of EVLWi on admission to PICU, as well as higher A-aDO(2) and OI, and lower PaO(2) and PaO(2)/FIO(2) ratio. After 24 h EVLWi decreased significantly only in survivors. As a survival indicator, EVLWi has good sensitivity and good specificity. Changes in EVLWi, OI, and mean airway pressure had a time-dependent influence on survival that proved significant according to the Cox test. Survivors spent fewer hours on mechanical ventilation. We detected a correlation of EVLWi with percent fluid overload and pulmonary permeability.
CONCLUSIONS: Like OI and mean airway pressure, EVLWi on admission to PICU is predictive of survival and of time needed on mechanical ventilation.
Authors:
Riccardo Lubrano; Corrado Cecchetti; Marco Elli; Caterina Tomasello; Giuliana Guido; Matteo Di Nardo; Raffaele Masciangelo; Elisabetta Pasotti; Maria Antonietta Barbieri; Elena Bellelli; Nicola Pirozzi
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Publication Detail:
Type:  Journal Article     Date:  2010-09-29
Journal Detail:
Title:  Intensive care medicine     Volume:  37     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  124-31     Citation Subset:  IM    
Affiliation:
Dipartimento di Pediatria, Policlinico Umberto I, Sapienza Università di Roma, Viale Regina Elena 324, 00161 Rome, Italy. riccardo.lubrano@uniroma1.it
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