Document Detail

Prognostic value of exercise echocardiography in 5,798 patients: is there a gender difference?
MedLine Citation:
PMID:  11849861     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study was designed to determine the effect of gender on the prognostic value of exercise echocardiography. BACKGROUND: Limited information exists regarding gender differences in prognostic value of exercise echocardiography. METHODS: We obtained follow-up (3.2 +/- 1.7 years) in 5,798 consecutive patients who underwent exercise echocardiography for evaluation of known or suspected coronary artery disease. RESULTS: There were 3,322 men (mean age 62 +/- 12 years) and 2,476 women (mean age 62 +/- 12 years) (p = 0.7). New or worsening wall motion abnormalities developed with exercise in 35% of men and 25% of women (p = 0.001). Cardiac events, including cardiac death (107 patients) and nonfatal myocardial infarction (148 patients), occurred in 5.3% of men and 3.1% of women (p = 0.001). Addition of the percentage of ischemic segments to the clinical and rest echocardiographic model provided incremental information in predicting cardiac events for both men (chi(2) = 137 to 143, p = 0.014) and women (chi(2) = 72 to 76, p = 0.046). By multivariate analysis, exercise electrocardiographic and exercise echocardiographic predictors of cardiac events in both men and women were workload and exercise wall motion score index. There was no significant interaction effect of rest echocardiography (p = 0.79), exercise electrocardiography (p = 0.38) or exercise echocardiography (p = 0.67) with gender. CONCLUSIONS: Although cardiac events occurred more frequently in men, the incremental value of exercise echocardiography was comparable in both genders. Of all exercise electrocardiographic and exercise echocardiographic variables, workload and exercise wall motion score index had the strongest association with outcome. The results of exercise echocardiography have comparable implications in both men and women.
Adelaide M Arruda-Olson; Eldyn M Juracan; Douglas W Mahoney; Robert B McCully; Veronique L Roger; Patricia A Pellikka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  39     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-18     Completed Date:  2002-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-31     Citation Subset:  AIM; IM    
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
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MeSH Terms
Blood Pressure / physiology
Coronary Artery Disease / complications,  physiopathology*,  ultrasonography*
Death, Sudden, Cardiac / etiology*
Echocardiography, Stress*
Exercise Test*
Follow-Up Studies
Heart Rate / physiology
Middle Aged
Myocardial Infarction / etiology*,  physiopathology,  ultrasonography
Predictive Value of Tests
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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