| Prognostic value of end-tidal carbon dioxide during exercise testing in heart failure. | |
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MedLine Citation:
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PMID: 16843545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The partial pressure of end-tidal carbon dioxide production (P(ET)CO2) at ventilatory threshold (VT) has been shown to be strongly correlated with cardiac output during exercise in patients with heart failure (HF), but few data are available regarding its prognostic utility. AIMS: The purpose of this study was to assess the ability of P(ET)CO2 to predict cardiac-related events in a group of subjects with HF. METHODS: One hundred and thirty subjects diagnosed with compensated HF underwent cardiopulmonary exercise testing (CPX). Peak oxygen consumption (VO2), the minute ventilation-carbon dioxide production (VE/VCO2) slope and P(ET)CO2 were determined. RESULTS: Receiver operating characteristic (ROC) curve analysis revealed that P(ET)CO2 at the ventilatory threshold (VT) was a significant predictor of cardiac-related events (ROC area=0.82, p<0.001). The optimal P(ET)CO2 at a VT threshold value for separating high (< or =) and low (>) risk groups was 36.1 mm Hg (77% sensitivity, 69% specificity). In a multivariate Cox regression analysis, P(ET)CO2 at VT added significant predictive value to the VE/VCO2 slope and peak VO2. CONCLUSION: These results indicate that P(ET)CO2 during CPX is a significant predictor of cardiac-related events in patients with HF. Clinical assessment of this variable in patients with HF undergoing CPX may therefore be warranted. |
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Authors:
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Ross Arena; Marco Guazzi; Jonathan Myers |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2006-07-14 |
Journal Detail:
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Title: International journal of cardiology Volume: 117 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-19 Completed Date: 2007-05-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 103-8 Citation Subset: IM |
Affiliation:
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Department of Physical Therapy, Box 980224, Virginia Commonwealth University, Health Sciences Campus, Richmond, Virginia 23298-0224, United States. raarena@vcu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breath Tests Carbon Dioxide / metabolism* Exercise Test* Female Heart Failure / diagnosis*, metabolism* Humans Male Middle Aged Multivariate Analysis Prognosis Regression Analysis Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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