Document Detail


Prognostic value of electrocardiographic monitoring of patients with severe diphtheria.
MedLine Citation:
PMID:  7620007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical, the 12-lead, and the 24-hour electrocardiographic findings in 15 consecutively studied Vietnamese children (aged 7 months to 16 years) with severe diphtheria were documented. Five patients died, three from respiratory arrest and two from cardiogenic shock; one of these two patients had complete heart block that necessitated insertion of a pacemaker. Electrocardiographic abnormalities were detected by 24-hour monitoring in all 15 cases, even though most patients had no clinical signs of myocarditis. Rates of supraventricular and ventricular ectopy were elevated and remained high long after other clinical manifestations were no longer noted. The degree of ventricular ectopy at the time of presentation was significantly associated with fatal outcome. In this series, more than two ventricular ectopic beats on a recording upon admission to the hospital predicted fatal outcome with 100% sensitivity and 100% specificity. A variety of nonsustained bradyarrhythmias and tachyarrhythmias were also observed up until discharge from the hospital. The time course of recovery from diphtheritic myocarditis is longer than has been appreciated previously.
Authors:
D B Bethell; Nguyen Minh Dung; Ha Thi Loan; Le Thi Nguyet Minh; Nguyen Quoc Dung; N P Day; N J White
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  20     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1259-65     Citation Subset:  IM    
Affiliation:
Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Arrhythmias, Cardiac / etiology
Child
Child, Preschool
Diphtheria / mortality,  physiopathology*
Electrocardiography
Female
Humans
Infant
Male
Prognosis
Grant Support
ID/Acronym/Agency:
//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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