Document Detail


Prognostic value of dual time point (18) F-fluorodeoxyglucose positron emission tomography in patients with pulmonary sarcoidosis.
MedLine Citation:
PMID:  21382131     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY AT A GLANCE: The retention index of standardized uptake value (RI-SUV), as calculated from dual time point (18) F-FDG PET delayed imaging, provided better diagnostic accuracy for persistent lung involvement in sarcoidosis at one year compared with SUV or (67) Ga uptake. This technique may be a useful index of persistent inflammation in patients with pulmonary sarcoidosis. ABSTRACT: Background and objective:  The value of dual time point (18) F-FDG PET was investigated to predict the prognosis of patients with pulmonary sarcoidosis. Methods:  Twenty-one patients with pulmonary sarcoidosis underwent (18) F-FDG PET examinations at two time points: an early scan at 60 min and a delayed scan at 180 min after injection of (18) F-FDG. Standardized uptake values (SUVs) at the two time points and the retention index (RI-SUV) calculated from these were evaluated. To evaluate disease progression, all patients underwent chest CT one year after (18) F-FDG PET. Using these results, the accuracy of (18) F-FDG PET parameters and (67) Ga uptake for predicting disease persistence were compared, and the correlations between those parameters and serum markers were assessed. Results:  RI-SUV was significantly higher in patients with increased or unchanged pulmonary lesions at follow-up CT (persistent group; 21.3 ± 9.6%) than in patients with improved pulmonary lesions (improved group; -9.2 ± 28.6%, P = 0.0075). The diagnostic accuracy of RI-SUV in the persistent group was significantly greater than that of early SUV or (67) Ga uptake, and serum soluble IL-2 receptor showed a significant correlation with RI-SUV. Conclusions:  RI-SUV showed better diagnostic accuracy compared with early SUV or (67) Ga uptake, in patients with persistent lung involvement at one year. It may be a useful measure of persistent inflammation in patients with pulmonary sarcoidosis.
Authors:
Yukihiro Umeda; Yoshiki Demura; Miwa Morikawa; Shingo Ameshima; Tatsuro Tsuchida; Yasuhisa Fujibayashi; Hidehiko Okazawa; Takeshi Ishizaki
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-8
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology.
Affiliation:
Department of Respiratory Medicine, Department of Radiology and Biomedical Imaging Research Center, University of Fukui, Fukui, Department of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Kanazawa-shi Ishikawa, Japan.
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