Document Detail

Prognostic value of dual time point (18) F-fluorodeoxyglucose positron emission tomography in patients with pulmonary sarcoidosis.
MedLine Citation:
PMID:  21382131     Owner:  NLM     Status:  Publisher    
SUMMARY AT A GLANCE: The retention index of standardized uptake value (RI-SUV), as calculated from dual time point (18) F-FDG PET delayed imaging, provided better diagnostic accuracy for persistent lung involvement in sarcoidosis at one year compared with SUV or (67) Ga uptake. This technique may be a useful index of persistent inflammation in patients with pulmonary sarcoidosis. ABSTRACT: Background and objective:  The value of dual time point (18) F-FDG PET was investigated to predict the prognosis of patients with pulmonary sarcoidosis. Methods:  Twenty-one patients with pulmonary sarcoidosis underwent (18) F-FDG PET examinations at two time points: an early scan at 60 min and a delayed scan at 180 min after injection of (18) F-FDG. Standardized uptake values (SUVs) at the two time points and the retention index (RI-SUV) calculated from these were evaluated. To evaluate disease progression, all patients underwent chest CT one year after (18) F-FDG PET. Using these results, the accuracy of (18) F-FDG PET parameters and (67) Ga uptake for predicting disease persistence were compared, and the correlations between those parameters and serum markers were assessed. Results:  RI-SUV was significantly higher in patients with increased or unchanged pulmonary lesions at follow-up CT (persistent group; 21.3 ± 9.6%) than in patients with improved pulmonary lesions (improved group; -9.2 ± 28.6%, P = 0.0075). The diagnostic accuracy of RI-SUV in the persistent group was significantly greater than that of early SUV or (67) Ga uptake, and serum soluble IL-2 receptor showed a significant correlation with RI-SUV. Conclusions:  RI-SUV showed better diagnostic accuracy compared with early SUV or (67) Ga uptake, in patients with persistent lung involvement at one year. It may be a useful measure of persistent inflammation in patients with pulmonary sarcoidosis.
Yukihiro Umeda; Yoshiki Demura; Miwa Morikawa; Shingo Ameshima; Tatsuro Tsuchida; Yasuhisa Fujibayashi; Hidehiko Okazawa; Takeshi Ishizaki
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-8
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology.
Department of Respiratory Medicine, Department of Radiology and Biomedical Imaging Research Center, University of Fukui, Fukui, Department of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Kanazawa-shi Ishikawa, Japan.
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