Document Detail

Prognostic value of dual-time-point 18F-fluorodeoxyglucose positron emission tomography in patients with pulmonary sarcoidosis.
MedLine Citation:
PMID:  21382131     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: The value of dual-time- point (18) F-FDG PET was investigated to predict the prognosis of patients with pulmonary sarcoidosis.
METHODS: Twenty-one patients with pulmonary sarcoidosis underwent (18) F-FDG PET examinations at two time points: an early scan at 60min and a delayed scan at 180min after injection of (18) F-FDG. Standardized uptake values (SUVs) at the two time points and the retention index (RI-SUV) calculated from these were evaluated. To evaluate disease progression, all patients underwent chest CT 1year after (18) F-FDG PET. Using these results, the accuracy of (18) F-FDG PET parameters and (67) Ga uptake for predicting disease persistence were compared, and the correlations between those parameters and serum markers were assessed.
RESULTS:   RI-SUV was significantly higher in patients with increased or unchanged pulmonary lesions at follow-up CT (persistent group; 21.3±9.6%) than in patients with improved pulmonary lesions (improved group; -9.2±28.6%, P=0.0075). The diagnostic accuracy of RI-SUV in the persistent group was significantly greater than that of early SUV or (67) Ga uptake, and serum soluble IL-2 receptor showed a significant correlation with RI-SUV.
CONCLUSIONS: RI-SUV showed better diagnostic accuracy compared with early SUV or (67) Ga uptake, in patients with persistent lung involvement at 1year. It may be a useful measure of persistent inflammation in patients with pulmonary sarcoidosis.
Yukihiro Umeda; Yoshiki Demura; Miwa Morikawa; Shingo Ameshima; Tatsuro Tsuchida; Yasuhisa Fujibayashi; Hidehiko Okazawa; Takeshi Ishizaki
Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  16     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-26     Completed Date:  2011-08-31     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  713-20     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors; Respirology © 2011 Asian Pacific Society of Respirology.
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MeSH Terms
Fluorodeoxyglucose F18 / diagnostic use*
Gallium Radioisotopes / diagnostic use
Middle Aged
Positron-Emission Tomography / methods*
Predictive Value of Tests
Radiography, Thoracic / methods
Receptors, Interleukin-2 / blood
Sarcoidosis, Pulmonary / diagnosis*
Tomography, X-Ray Computed / methods
Reg. No./Substance:
0/Gallium Radioisotopes; 0/Receptors, Interleukin-2; 0Z5B2CJX4D/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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