Document Detail

Prognostic value of direct bilirubin in neonatal hyperbilirubinemia.
MedLine Citation:
PMID:  17901666     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the prognostic value of indirect and direct hyperbilirubinemia in neonates with jaundice. METHODS: A cohort of 92 consecutive neonates reporting with hyperbilirubinemia to a tertiary care center were followed up till well and discharged, or, till death to assess risk and rate of mortality. RESULTS: The baseline median values of total, direct and indirect bilirubin in the cohort of 21.8, 1.6 and 18.6 mg/dl, respectively, were used as cut-offs for high and low levels. Using survival analyses i.e. Kaplan-Meier plots, logrank tests and multivariate Cox proportional hazards regression models to adjust for other strong predictors such as receipt of breastfeeding, being small for gestational age (SGA) and exchange transfusion, high direct bilirubin (> or = median value of 1.6 mg/dl) was independently associated with a higher and faster mortality. CONCLUSION: This study showed that direct bilirubin has independent and additive prognostic value and due attention should be given to newborns with raised levels.
Manju Mamtani; Archana Patel; Ramesh Renge; Hemant Kulkarni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  74     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-28     Completed Date:  2007-11-08     Revised Date:  2009-07-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  819-22     Citation Subset:  IM    
Lata Medical Research Foundation, Nagpur, India.
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MeSH Terms
Bilirubin / blood*
Hyperbilirubinemia / blood*,  complications,  mortality
Infant, Newborn / blood*
Poisson Distribution
Predictive Value of Tests
Proportional Hazards Models
ROC Curve
Reg. No./Substance:
Comment In:
Indian J Pediatr. 2008 Feb;75(2):193; author reply 193-4   [PMID:  18334807 ]

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