Document Detail

Prognostic value of contrast stress echocardiography in patients with image quality too limited for traditional noncontrast harmonic echocardiography.
MedLine Citation:
PMID:  14712182     Owner:  NLM     Status:  MEDLINE    
Clinical data and contrast stress echocardiography (CSE) results were analyzed in 283 patients to establish the prognostic value of CSE for patients with limited echocardiogram image quality at baseline. The mean follow-up period was 736 +/- 337 days. Only 7 patients (2.5%) had nondiagnostic image quality with contrast enhancement. During follow-up, 24 cardiac events (8.5%) occurred (5 cardiac-related deaths, 2 nonfatal myocardial infarction, 17 coronary revascularizations). Overall sensitivity, specificity, and positive and negative predictive values were 60.9%, 76.8%, 19.7%, and 95.5%, respectively. Kaplan-Meier event-free survival was higher for patients with a negative CSE result as compared with those with a positive CSE finding (P <.0001). In a multivariate Cox proportional hazards model, positive CSE was the strongest predictor of cardiac events (risk ratio 3.7; 95% confidence interval 1.6-8.7). CSE can successfully predict cardiac events for patients with limited noncontrast echocardiographic image quality. A negative CSE result conferred a good prognosis.
Naoyuki Yokoyama; Karl Q Schwarz; Sherry D Steinmetz; Xiang Li; Xucai Chen
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  17     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-08     Completed Date:  2004-04-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
University of Rochester and the Rochester Center for Biomedical Ultrasound, Rochester, New York, USA.
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MeSH Terms
Adrenergic beta-Agonists / diagnostic use
Blood Pressure / physiology
Cardiomyopathy, Dilated / diagnosis,  epidemiology,  physiopathology
Disease-Free Survival
Dobutamine / diagnostic use
Echocardiography, Stress*
Follow-Up Studies
Heart Rate / physiology
Image Enhancement*
Middle Aged
Multivariate Analysis
Myocardial Ischemia / diagnosis,  epidemiology,  physiopathology
New York
Predictive Value of Tests
Risk Factors
Sensitivity and Specificity
Stroke Volume / physiology
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 34368-04-2/Dobutamine

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