Document Detail

Prognostic value of combination of heart-type fatty acid-binding protein and ischemia-modified albumin in patients with acute coronary syndromes and normal troponin T values.
MedLine Citation:
PMID:  19140206     Owner:  NLM     Status:  MEDLINE    
Recent studies have suggested that heart-type fatty acid-binding protein (H-FABP) may detect ongoing myocardial damage involved in the progression of acute coronary syndromes (ACS). This study was prospectively designed to examine whether the combination of H-FABP, a marker for ongoing myocardial damage, and ischemia-modified albumin (IMA), a marker for myocardial ischemia, would effectively diagnose patients with ACS. H-FABP values above 1.5 microg/l can be correctly measured via an ELISA and 6 microg/l is the currently used cut-off value (1-3). We measured serum H-FABP and IMA of 108 patients on admission within 12 hr after onset of chest pain and normal troponin T. serum samples from ACS group (n=82) had decreased capacity of ACB [64 (61-67) U/ml] compared with non-ACS ischemic chest pain group (n=26) samples [75 (71-78) U/ml] (P<0.05). The combination of IMA and H-FABP usually had better sensitivity [96.3% (92.2-100%)] (P<0.05) and accuracy [92.6 (87.7-97.5%)] (P<0.05) than when individually used. Thus, the combination of H-FABP and IMA measurements after initiation of chest pain may be highly effective for risk stratification in patients with ACS and normal cardiac troponin T.
Cui Liyan; Zhang Jie; Hu Xiaozhou
Related Documents :
6105436 - Early intravenous atenolol treatment in suspected acute myocardial infarction. prelimin...
9591526 - Clinical characteristics and follow-up of patients with chest pain and normal coronary ...
8110616 - Mechanisms of pain in angina pectoris--a critical review of the adenosine hypothesis.
904036 - Therapeutic renal infarction.
12419296 - Von willebrand factor and coronary heart disease: prospective study and meta-analysis.
1985766 - Intrapericardial infusion of 5-fluorouracil. an unusual complication of a hickman cathe...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  23     ISSN:  1098-2825     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Wiley-Liss, Inc.
Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Coronary Syndrome / blood,  diagnosis*
Biological Markers / blood
Chest Pain / diagnosis
Fatty Acid-Binding Proteins / blood*
Middle Aged
Myocardial Ischemia / blood,  diagnosis
Predictive Value of Tests
ROC Curve
Reproducibility of Results
Sensitivity and Specificity
Serum Albumin / analysis*
Troponin T / blood*
Reg. No./Substance:
0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 0/Serum Albumin; 0/Troponin T

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Laboratory diagnosis of syphilis with automated immunoassays.
Next Document:  Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus...