| Prognostic value of combination of heart-type fatty acid-binding protein and ischemia-modified albumin in patients with acute coronary syndromes and normal troponin T values. | |
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MedLine Citation:
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PMID: 19140206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have suggested that heart-type fatty acid-binding protein (H-FABP) may detect ongoing myocardial damage involved in the progression of acute coronary syndromes (ACS). This study was prospectively designed to examine whether the combination of H-FABP, a marker for ongoing myocardial damage, and ischemia-modified albumin (IMA), a marker for myocardial ischemia, would effectively diagnose patients with ACS. H-FABP values above 1.5 microg/l can be correctly measured via an ELISA and 6 microg/l is the currently used cut-off value (1-3). We measured serum H-FABP and IMA of 108 patients on admission within 12 hr after onset of chest pain and normal troponin T. serum samples from ACS group (n=82) had decreased capacity of ACB [64 (61-67) U/ml] compared with non-ACS ischemic chest pain group (n=26) samples [75 (71-78) U/ml] (P<0.05). The combination of IMA and H-FABP usually had better sensitivity [96.3% (92.2-100%)] (P<0.05) and accuracy [92.6 (87.7-97.5%)] (P<0.05) than when individually used. Thus, the combination of H-FABP and IMA measurements after initiation of chest pain may be highly effective for risk stratification in patients with ACS and normal cardiac troponin T. |
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Authors:
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Cui Liyan; Zhang Jie; Hu Xiaozhou |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of clinical laboratory analysis Volume: 23 ISSN: 1098-2825 ISO Abbreviation: J. Clin. Lab. Anal. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-08-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801384 Medline TA: J Clin Lab Anal Country: United States |
Other Details:
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Languages: eng Pagination: 14-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood,
diagnosis* Adult Aged Biological Markers / blood Chest Pain / diagnosis China Fatty Acid-Binding Proteins / blood* Female Humans Male Middle Aged Myocardial Ischemia / blood, diagnosis Predictive Value of Tests Prognosis ROC Curve Reproducibility of Results Sensitivity and Specificity Serum Albumin / analysis* Troponin T / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 0/Serum Albumin; 0/Troponin T |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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