Document Detail

Prognostic value of the cold pressor test for hypertension based on 28-year follow-up.
MedLine Citation:
PMID:  7896565     Owner:  NLM     Status:  MEDLINE    
Several stress tests have been used to predict the development of hypertension. No conclusion, however, has been reached on the effectiveness of these tests as a predictor of hypertension in later years. The present study examines the prognostic values of blood pressure response to cold and resting blood pressure for future hypertension, based on a follow-up study over 28 years of 824 individuals (mean age: 35.8 +/- 10.8 yr) whose resting blood pressure had been normal at baseline. A significant determinant of blood pressure response to cold stimulus was age in these normotensive subjects. A higher response was observed as age increased. There was also a significant seasonal variation in blood pressure response to cold, suggesting the need to standardize a time to perform the cold pressor test. Hypertension has developed in 343 individuals during the 28 years of follow-up, with a mean incidence rate of 24.6 per 10(3) person-years. Both systolic and diastolic responses were significant as a predictor of future hypertension after adjusting for attained age, resting blood pressure, and body mass index at baseline. However, a comparison between resting blood pressure and response to cold indicated that the cold pressor test is not as effective a predictor of hypertension as resting blood pressure. Radiation exposure was not significant either as a background risk or as a possible modifier of the relationship between the blood pressure response and the development of hypertension. The current results suggest that blood pressure response to cold supplements resting blood pressure for predicting hypertension.
F Kasagi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Hiroshima journal of medical sciences     Volume:  43     ISSN:  0018-2052     ISO Abbreviation:  Hiroshima J. Med. Sci.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-04-27     Completed Date:  1995-04-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0421060     Medline TA:  Hiroshima J Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  93-103     Citation Subset:  IM    
Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
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MeSH Terms
Age Factors
Aged, 80 and over
Blood Pressure / physiology*
Cold Temperature / diagnostic use*
Exercise Test
Follow-Up Studies
Hypertension / diagnosis,  epidemiology*,  physiopathology
Middle Aged
Predictive Value of Tests

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