Document Detail


Prognostic value of clinical, laboratory, and morphological factors in patients with primary focal segmental glomerulosclerosis - distribution of pathological variants in the Croatian population.
MedLine Citation:
PMID:  19789521     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Scant data are available on the prognosis and distribution of subtypes of focal segmental glomerulosclerosis (FSGS) using the new Columbia classification in European populations. We assessed the predictive value of the clinical, laboratory, and morphological data obtained at the time of diagnosis, established on the basis of kidney biopsy, for the prognosis of primary FSGS. MATERIAL/METHODS: Sixty adults with FSGS were included in the study. Patients' clinical status, routine laboratory data, and histopathological findings were correlated with patients' remission status after a 5-year follow-up and patients' injury score (IS). RESULTS: Thirty-eight patients had remission of the disease and 22 patients did not. A value of IS>0.84 was more often found in patients who did not reach remission, whereas IS <0.34 was more frequent in patients who did reach remission (P=0.002). Serum creatinine and creatinine clearance correlated with IS (P<0.001), but proteinuria showed no correlation. FSGS subtypes were distributed as follows: tip variant in 3 (5%) patients, cellular variant in 4 (7%), not otherwise specified variant in 15 (25%), and perihilar variant in 38 (63%) patients. Collapsing variant of FSGS was not found in any of the patients included in the study. CONCLUSIONS: Injury score is the most reliable prognostic predictor in patients with primary FSGS. Patients with perihilar variant were most frequent, whereas collapsing variant was not found at all in the Croatian population.
Authors:
Jadranka Vlasi??-Matas; Merica Glavina Durdov; Vesna Capkun; Kresimir Galesi??
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  15     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-30     Completed Date:  2010-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  PH121-128     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Split University Hospital Center, Split, Croatia. jadranka.vlasic-matas@st.t-com.hr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Clinical Laboratory Techniques*
Croatia
European Continental Ancestry Group*
Female
Glomerulosclerosis, Focal Segmental / complications,  diagnosis*,  drug therapy,  pathology*
Humans
Hypertension / complications
Immunosuppression
Immunosuppressive Agents / therapeutic use
Inflammation / complications
Male
Middle Aged
Prognosis
Remission Induction
Young Adult
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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