| Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis. | |
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MedLine Citation:
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PMID: 23279060 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: The aim of the study was to evaluate the significance of total bilirubin, aspartate transaminase (AST), alanine transaminase and gamma-glutamyltransferase (GGT) for predicting outcome in sepsis-associated cholestasis. METHODS: A retrospective cohort review of the hospital records was performed in 181 neonates admitted to the Neonatal Care Unit. A comparison was performed between subjects with low and high liver values based on cut-off values from ROC analysis. We defined poor prognosis to be when a subject had prolonged cholestasis of more than 3.5 months, developed severe sepsis, septic shock or had a fatal outcome. RESULTS: The majority of the subjects were male (56%), preterm (56%) and had early onset sepsis (73%). The poor prognosis group had lower initial values of GGT compared with the good prognosis group (P = 0.003). Serum GGT (cut-off value of 85.5 U/L) and AST (cut-off value of 51 U/L) showed significant correlation with the outcome following multivariate analysis. The odds ratio (OR) of low GGT and high AST were OR 4.3 (95% CI:1.6 to11.8) and OR 2.9 (95% CI:1.1 to 8), respectively, for poor prognosis. In subjects with normal AST values, those with low GGT value had relative risk of 2.52 (95% CI:1.4 to 3.5) for poorer prognosis compared with those with normal or high GGT. CONCLUSION: Serum GGT and AST values can be used to predict the prognosis of patients with sepsis-associated cholestasis. |
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Authors:
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Hanifah Oswari; Ruth Karisma Widjaja; Rinawati Rohsiswatmo; Geoffrey Cleghorn |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-21 |
Journal Detail:
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Title: Journal of paediatrics and child health Volume: - ISSN: 1440-1754 ISO Abbreviation: J Paediatr Child Health Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Journal of Paediatrics and Child Health © 2012 Paediatrics and Child Health Division (Royal Australasian College of Physicians). |
Affiliation:
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Divisions of Gastrohepatology, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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