Document Detail


Prognostic value of activated toll-like receptor-4 in monocytes following acute myocardial infarction.
MedLine Citation:
PMID:  18360060     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study tested the hypothesis that activated toll-like receptor-4 (TLR-4) is closely related to combined major adverse clinical outcomes (MACO) [defined as advanced Killip score (> or = 3), overt congestive heart failure (CHF) (New York Heart Association functional class > or = 2) or 30-day death] in patients with ST-segment elevation (ST-se) acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI). We conducted a prospective cohort study in 43 consecutive patients with ST-se AMI of onset < 12 hours who were undergoing primary PCI. Blood samples for TLR-4 and serum level of tumor necrosis factor-alpha (TNF-alpha) were collected from 43 patients at 24 hours after AMI and from 20 normal outpatients. The experimental results revealed significantly higher baseline levels of TLR-4, TNF-alpha and white blood cell (WBC) count in the study patients than in normal control subjects (all P < 0.0001). Additionally, baseline levels of TLR-4, TNF-alpha , creatinine, peak level of CK-MB, and multiple vessel disease were significantly higher, whereas left ventricular performance was notably lower in patients (n = 18) with occurrence of MACO than in patients (n = 25) without occurrence of MACO (all P < 0.05). Furthermore, the level of lipopolysaccharide (LPS)-stimulated LTR-4 was significantly increased in MACO patients than in those without MACO (P < 0.0001). Moreover, LPS-stimulated TLR-4 was the most independent predictor of 30-day MACO (P < 0.01). In patients with ST-se AMI, activated TLR-4 is independently predictive of 30-day MACO.
Authors:
Jiunn-Jye Sheu; Li-Teh Chang; Chiang-Hua Chiang; Ali A Youssef; Chiung-Jen Wu; Fan-Yen Lee; Hon-Kan Yip
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International heart journal     Volume:  49     ISSN:  1349-2365     ISO Abbreviation:  -     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC..
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Transluminal, Percutaneous Coronary
Cohort Studies
Creatinine / blood
Female
Heart Ventricles / physiopathology
Humans
Leukocyte Count
Male
Middle Aged
Monocytes / chemistry*
Myocardial Infarction / blood,  diagnosis*,  therapy
Prognosis
Prospective Studies
Toll-Like Receptor 4 / blood*
Tumor Necrosis Factor-alpha / blood
Chemical
Reg. No./Substance:
0/Toll-Like Receptor 4; 0/Tumor Necrosis Factor-alpha; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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