Document Detail


Prognostic value of acetylcholine challenge test: a prospective study.
MedLine Citation:
PMID:  6722054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eleven hundred and nine iron mine workers aged 35 to 55 with normal chest radiographs were submitted to a pulmonary examination consisting of a questionnaire, a clinical examination, and pulmonary function testing including an acetylcholine challenge test. A positive response (decrease of FEV1 of more than 10%) was observed in 210 subjects (Ace+). The remaining 899 had a negative response (Ace-). Bronchitis, asthma, dyspnoea, and obstructive syndrome were more frequent in the Ace+ group. Five years later, 820 subjects were reexamined: occasional cough and sputum and chronic bronchitis appeared more frequently among subjects without symptoms at the first examination but with a positive acetylcholine challenge test. The obstructive syndrome was more often observed and regressed more rarely in the Ace+ group. The results confirm the use of a test of bronchial hyperreactivity as a means of identifying subjects at risk from chronic obstructive lung disease.
Authors:
Q T Pham; J M Mur; N Chau; M Gabiano; J C Henquel; D Teculescu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of industrial medicine     Volume:  41     ISSN:  0007-1072     ISO Abbreviation:  Br J Ind Med     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-06-22     Completed Date:  1984-06-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370637     Medline TA:  Br J Ind Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / diagnostic use*
Adult
Bronchial Provocation Tests*
Humans
Iron
Lung Diseases, Obstructive / diagnosis
Middle Aged
Mining
Occupational Diseases / diagnosis*
Prognosis
Prospective Studies
Respiratory Function Tests
Respiratory Tract Diseases / diagnosis*
Chemical
Reg. No./Substance:
51-84-3/Acetylcholine; 7439-89-6/Iron
Comments/Corrections

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