Document Detail

Prognostic value of QT interval and QT dispersion in patients with left ventricular systolic dysfunction: results from a cohort of 2265 patients with an ejection fraction of < or =40%.
MedLine Citation:
PMID:  12514665     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increased QT interval and QT dispersion have been associated with higher mortality in population-based studies and in patients with myocardial infarction. However, the prognostic significance of these measurements in patients with left ventricular (LV) systolic dysfunction is not clear. METHODS AND RESULTS: Rate corrected QT interval (QTc) and QT dispersion (QTd) were measured by means of an automated method from digitized echocardiograms in 2265 patients with an LV ejection fraction < or =40% and were related to survival. Increased QTc was strongly related to mortality in the whole group and in subsets on the basis of age and the level of LV systolic dysfunction. There was a graded increase in mortality rate with an increase in QTc. The effect of QTc on mortality was incremental to the effects of age and ejection fraction. QT interval was measurable in > or =6 leads in 1193 patients in whom QTd was computed. QTd higher than the mean value of 35 ms was associated with an increase in all cause mortality (P =.04). Its mortality impact was most pronounced in the older patients, patients with more severe LV dysfunction, and patients with increased QTc. CONCLUSIONS: Both QTc prolongation and increased QTd are associated with higher mortality rate in patients with moderate and severe LV dysfunction.
Sriram Padmanabhan; Helme Silvet; Jatin Amin; Ramdas G Pai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  145     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-06     Completed Date:  2003-03-06     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-8     Citation Subset:  AIM; IM    
Department of Cardiology, Loma Linda University and VA Medical Center, Loma Linda, Calif 92354, USA.
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MeSH Terms
Cohort Studies
Follow-Up Studies
Long QT Syndrome / mortality
Middle Aged
Predictive Value of Tests
Retrospective Studies
Stroke Volume*
Survival Rate
Ventricular Dysfunction, Left / diagnosis*,  mortality,  physiopathology

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