| Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 17314108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The 6 min walk test (6-MWT) is a simple and popular test for evaluating functional status in patients with chronic heart failure (CHF). However, the prognostic value of the 6-MWT in a large, representative sample of CHF patients, and in patients with different degrees of left ventricular systolic dysfunction (LVSD) remains unclear. METHODS AND RESULTS: Of an initial population of 1592 patients, 212 died representing a crude death rate of 13.3%. In surviving patients, the median time to follow-up period was 36.6 months [inter-quartile range (IQR) 28-45 months]. Five variables remained independent predictors of all-cause mortality; decreasing 6-MWT distance, self-perceived signs of breathlessness at night (SOBAN), beta-blocker usage, elevated log NT-proBNP, and reduced haemoglobin concentration. We also dichotomized our analysis by LVSD status (<or=mild LVSD or >mild LVSD). For patients with >mild LVSD, 6-MWT remained an important prognostic indicator but not in patients with <or=mild LVSD. CONCLUSION: The 6-MWT is an important independent predictor of mortality in CHF patients, and this was especially evident in patients with >mild LVSD. The 6-MWT provides little prognostic utility in patients with <or=mild LVSD. While log NT-proBNP was the most potent independent predictor, an additive prognostic effect was evident with the additional selection of 6-MWT. Patients' self-perceived symptoms, especially SOBAN was an independent predictor of mortality in our patients. |
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Authors:
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Lee Ingle; Alan S Rigby; Sean Carroll; Ron Butterly; Rod F King; Carlton B Cooke; John G J F Cleland; Andrew L Clark |
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Publication Detail:
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Type: Journal Article Date: 2007-02-21 |
Journal Detail:
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Title: European heart journal Volume: 28 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-07 Completed Date: 2007-11-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 560-8 Citation Subset: IM |
Affiliation:
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Carnegie Research Institute, Leeds Metropolitan University, Beckett's Park Campus, Leeds LS6 3QS, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Chronic Disease Exercise Test Female Heart Failure / mortality*, physiopathology Humans Male Prognosis Regression Analysis Survival Analysis Ventricular Dysfunction, Left / mortality*, physiopathology Walking / physiology* |
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