| Prognostic value of 1H-MRS in neonatal encephalopathy. | |
| | |
MedLine Citation:
|
PMID: 16647995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to determine the prognostic value of proton magnetic resonance spectroscopy in neonatal encephalopathy. Studies were carried out in 11 consecutive term newborns with encephalopathy probably caused by hypoxic-ischemic injury. The clinical evaluation included pregnancy data, labor conditions, encephalopathy grade, presence of seizures, and necessity of antiepileptic drug therapy. Polygraphic recordings were obtained in all cases. Interest areas evaluated by spectroscopy were the basal ganglia and thalami. Among the cases, N-acetylaspartate/creatine, choline/creatine, and lactate/creatine ratios were calculated and related to the clinical variables, polygraphic recordings, and 6-month neurodevelopmental outcome. Abnormal follow-up occurred in 5 of 11 patients (45.4%) and was clearly related to an Apgar score <5 at 5 minutes (P = 0.003), encephalopathy grade (P = 0.02), early neonatal seizures (P = 0.02), and antiepileptic therapy (P = 0.01). No relationship was observed between spectroscopy results and polygraphic recordings profile. The lowest mean N-acetylaspartate/creatine ratio was observed in four of five patients with an adverse outcome and, although not statistically significant, demonstrated a clear trend to unfavorable follow-up (t test = 0.06). The choline/creatine ratios could not be related to follow-up in our sample. The most consistently observed abnormality on the spectra was the presence of the lactate peak in four of five patients with unfavorable outcome, with a high relative risk to determine evolution in the sample, relative risk 7.0 (chi2 = 0.01, 95% confidence interval = 1.1-42.9). |
| | |
Authors:
|
Luis Fernando Garcias da Silva; João Rubião Höefel Filho; Maurício Anés; Magda Lahorgue Nunes |
Related Documents
:
|
8455985 - Incidence and pattern of jaundice in healthy breast-fed infants during the first month ... 3342595 - Seizures in the neonatal intensive care unit of the 1980s. types, etiologies, timing. 22966025 - Incidence of chronic bilirubin encephalopathy in canada, 2007-2008. 20008595 - Early diagnosis of neonatal cholestatic jaundice: test at 2 weeks. 19372695 - Prenatal cocaine exposure and prolonged focus attention. poor infant information proces... 7597655 - Oral contraceptive use after conception in relation to the risk of congenital urinary t... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Pediatric neurology Volume: 34 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-05-01 Completed Date: 2006-07-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 360-6 Citation Subset: IM |
Affiliation:
|
Division of Neurology and Clinical Neurophysiology Laboratory, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul School of Medicine, Porto Alegre, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apgar Score Aspartic Acid / analogs & derivatives, metabolism Asphyxia Neonatorum / diagnosis*, epidemiology, metabolism Basal Ganglia / metabolism Choline / metabolism Creatine / metabolism Creatinine / metabolism Female Follow-Up Studies Humans Hypoxia-Ischemia, Brain / diagnosis*, epidemiology, metabolism Infant, Newborn Lactic Acid / metabolism Magnetic Resonance Spectroscopy* Male Polysomnography Predictive Value of Tests Pregnancy Pregnancy Complications / diagnosis, epidemiology, metabolism Prognosis Protons Risk Factors Thalamus / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Protons; 50-21-5/Lactic Acid; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 60-27-5/Creatinine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intranasal midazolam vs rectal diazepam in acute childhood seizures.
Next Document: Level of tau protein in children treated for acute lymphoblastic leukemia.